Academic Journal
Point estimation, confidence intervals, and P‐values for optimal adaptive two‐stage designs with normal endpoints
| العنوان: | Point estimation, confidence intervals, and P‐values for optimal adaptive two‐stage designs with normal endpoints |
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| المؤلفون: | Meis, Jan, Pilz, Maximilian, Bokelmann, Björn, Herrmann, Carolin, Rauch, Geraldine, Kieser, Meinhard |
| سنة النشر: | 2024 |
| المجموعة: | TU Berlin: Deposit Once |
| مصطلحات موضوعية: | 600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit, 500 Naturwissenschaften und Mathematik::510 Mathematik::510 Mathematik, bias, confidence intervals, optimal adaptive designs, P‐values, point estimation |
| الوصف: | Due to the dependency structure in the sampling process, adaptive trial designs create challenges in point and interval estimation and in the calculation of P-values. Optimal adaptive designs, which are designs where the parameters governing the adaptivity are chosen to maximize some performance criterion, suffer from the same problem. Various analysis methods which are able to handle this dependency structure have already been developed. In this work, we aim to give a comprehensive summary of these methods and show how they can be applied to the class of designs with planned adaptivity, of which optimal adaptive designs are an important member. The defining feature of these kinds of designs is that the adaptive elements are completely prespecified. This allows for explicit descriptions of the calculations involved, which makes it possible to evaluate different methods in a fast and accurate manner. We will explain how to do so, and present an extensive comparison of the performance characteristics of various estimators between an optimal adaptive design and its group-sequential counterpart. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0277-6715 1097-0258 |
| Relation: | https://depositonce.tu-berlin.de/handle/11303/21512; https://doi.org/10.14279/depositonce-20312 |
| DOI: | 10.14279/depositonce-20312 |
| الاتاحة: | https://depositonce.tu-berlin.de/handle/11303/21512 https://doi.org/10.14279/depositonce-20312 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.CC02E593 |
| قاعدة البيانات: | BASE |
| تدمد: | 02776715 10970258 |
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| DOI: | 10.14279/depositonce-20312 |