Academic Journal
COVID-19 in Lung Transplant Recipients
| العنوان: | COVID-19 in Lung Transplant Recipients |
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| المؤلفون: | Messika, Jonathan, Eloy, Philippine, Roux, Antoine, Hirschi, Sandrine, Nieves, Ana, Le Pavec, Jérôme, Sénéchal, Agathe, Saint Raymond, Christelle, Carlier, Nicolas, Demant, Xavier, Le Borgne, Aurélie, Tissot, Adrien, Debray, Marie Pierre, Beaumont, Laurence, Renaud-Picard, Benjamin, Reynaud-Gaubert, Martine L., Mornex, Jean-François, Falque, Loïc, Boussaud, Véronique, Jougon, Jacques B., Mussot, Sacha, Mal, Hervé J. |
| المساهمون: | AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), INSERM UMR1152, Service de Pneumologie et Transplantation Pulmomaire, Hôpital Bichat - Claude Bernard, Assistance Publique - Hôpitaux de Paris (AP-HP), Département d’Epidémiologie et Recherche Clinique AP-HP Hôpital Bichat - Claude Bernard (CIC‑EC 1425), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Les Hôpitaux Universitaires de Strasbourg (HUS), Aix Marseille Université (AMU), Hypertension pulmonaire : physiopathologie et innovation thérapeutique (HPPIT), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, hôpital Louis-Pradel, CHU de Lyon, 69500 Bron, France., Centre Hospitalier Universitaire CHU Grenoble (CHUGA), AP-HP - Hôpital Cochin Broca Hôtel Dieu Paris, Hôpital Haut-Lévêque CHU Bordeaux, CHU Bordeaux, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Hôpital Foch Suresnes, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Infections Virales et Pathologie Comparée - UMR 754 (IVPC), École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| المصدر: | ISSN: 0041-1337. |
| بيانات النشر: | HAL CCSD Lippincott, Williams & Wilkins |
| سنة النشر: | 2021 |
| المجموعة: | Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; BACKGROUND: A concern about the susceptibility of immunocompromised patients to the worldwide pandemic of coronavirus disease 2019 (COVID-19) has been raised. We aimed at describing COVID-19 infections in the French cohort of lung transplant (LT) patients. METHODS: Multicenter nationwide cohort study of all LT recipients with COVID-19 diagnosed from March 1 to May 19, 2020. Recipient main characteristics and their management were retrieved. Hospitalization characteristics, occurrence of complications and survival were analyzed. RESULTS: Thirty-five LT patients with a COVID-19 infection were included. Median age was 50.4 (40.6-62.9) years, 16 (45.7%) were female, and 80% were double-LT recipients. Infection was community-acquired in 25 (71.4%). Thirty-one (88.6%) required hospitalization, including 13 (41.9%) in the intensive care unit. The main symptoms of COVID-19 were fever, cough, and diarrhea, present in 71.4%, 54.3%, and 31.4% of cases, respectively. Extension of pneumonia on chest CT was moderate to severe in 51.4% of cases. Among the 13 critically ill patients, 7 (53.9%) received invasive mechanical ventilation. Thrombotic events occurred in 4 patients. Overall survival rate was 85.7% after a median follow-up of 50 days (41.0-56.5). Four of 5 nonsurvivors had had bronchial complications or intensification of immunosuppression in the previous weeks. On univariate analysis, overweight was significantly associated with risk of death (odds ratio, 16.0; 95% confidence interval, 1.5-170.6; P = 0.02). CONCLUSIONS: For the 35 LT recipients with COVID-19, the presentation was severe, requiring hospitalization in most cases, with a survival rate of 85.7%. Copyright |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33141808; hal-03127530; https://hal.science/hal-03127530; https://hal.science/hal-03127530/document; https://hal.science/hal-03127530/file/art_Ms%20COVID%20LT%20R1_defclean%20%281%29.pdf; PUBMED: 33141808; WOS: 000639592400036 |
| DOI: | 10.1097/TP.0000000000003508 |
| الاتاحة: | https://hal.science/hal-03127530 https://hal.science/hal-03127530/document https://hal.science/hal-03127530/file/art_Ms%20COVID%20LT%20R1_defclean%20%281%29.pdf https://doi.org/10.1097/TP.0000000000003508 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.CBDC0CF0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/TP.0000000000003508 |
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