Academic Journal
The Curies’ element: state of the art and perspectives on the use of radium in nuclear medicine
| العنوان: | The Curies’ element: state of the art and perspectives on the use of radium in nuclear medicine |
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| المؤلفون: | Franchi S., Asti M., Di Marco V., Tosato M. |
| المساهمون: | Franchi, S., Asti, M., Di Marco, V., Tosato, M. |
| بيانات النشر: | SPRINGERNATURE |
| سنة النشر: | 2023 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | Radium chelator, Radium-223, Radium-224, Targeted alpha therapy, α-emitters |
| الوصف: | Background: The alpha-emitter radium-223 (Ra-223) is presently used in nuclear medicine for the palliative treatment of bone metastases from castration-resistant prostate cancer. This application arises from its advantageous decay properties and its intrinsic ability to accumulate in regions of high bone turnover when injected as a simple chloride salt. The commercial availability of [Ra-223]RaCl2 as a registered drug (Xofigo (R)) is a further additional asset. Main body: The prospect of extending the utility of Ra-223 to targeted alpha-therapy of non-osseous cancers has garnered significant interest. Different methods, such as the use of bifunctional chelators and nanoparticles, have been explored to incorporate Ra-223 in proper carriers designed to precisely target tumor sites. Nevertheless, the search for a suitable scaffold remains an ongoing challenge, impeding the diffusion of Ra-223-based radiopharmaceuticals. Conclusion: This review offers a comprehensive overview of the current role of radium radioisotopes in nuclear medicine, with a specific focus on Ra-223. It also critically examines the endeavors conducted so far to develop constructs capable of incorporating Ra-223 into cancer-targeting drugs. Particular emphasis is given to the chemical aspects aimed at providing molecular scaffolds for the bifunctional chelator approach. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37947909; info:eu-repo/semantics/altIdentifier/wos/WOS:001103111500001; volume:8; issue:1; firstpage:38; journal:EJNMMI RADIOPHARMACY AND CHEMISTRY; https://hdl.handle.net/11577/3504190; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85176227156; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638329/pdf/41181_2023_Article_220.pdf |
| DOI: | 10.1186/s41181-023-00220-4 |
| الاتاحة: | https://hdl.handle.net/11577/3504190 https://doi.org/10.1186/s41181-023-00220-4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10638329/pdf/41181_2023_Article_220.pdf |
| رقم الانضمام: | edsbas.CBC6E25 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s41181-023-00220-4 |
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