Conference
Salvage laryngectomy for SCC of the larynx and hypopharynx : validated nomograms predicting outcomes
| العنوان: | Salvage laryngectomy for SCC of the larynx and hypopharynx : validated nomograms predicting outcomes |
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| المؤلفون: | Meulemans, Jeroen, Van Boven, Alexander, Debacker, Jens, Laenen, Annouschka, Delaere, Pierre, Vanlierde, Charlotte, Huvenne, Wouter, Vander Poorten, Vincent |
| المصدر: | 10th European Congress on Head & Neck Oncology, Abstracts |
| سنة النشر: | 2023 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences |
| الوصف: | Purpose Salvage total laryngectomy (STL) is often the preferred treatment for patients with residual, recurrent and second primary squamous cell carcinoma (SCC) of the larynx and hypopharynx after initial (chemo)radiation. Previously, we identified multiple solid prognosticators for oncological outcomes after STL, which could allow for postoperative risk stratification.In this study we aimed to design and validate nomograms, potentially allowing for a more individualized estimate of the expected oncological outcome. Methods We used a dataset of 290 patients who underwent STL in University Hospitals Leuven (Belgium) between 2002 and 2022. Kaplan Meier estimates were used for estimating overall survival (OS) and disease-free survival (DFS). The cumulative incidence function was used for estimating disease-specific survival (DSS). Cox proportional hazard models were used for the analysis of prognostic factors on oncological outcomes. A forward stepwise model selection procedure was used for the construction of multivariablemodels, adopting a 5% significance level for entering or leaving of variables. Harrel’s C-index was used to quantify the discriminative value of the multivariable models. Nomograms predicting 2- and 5-year OS, DFS and DSS were developed, either using variables which are identified pre-operatively (e.g. clinical tumor stage, tumor location, etc) or postoperatively (e.g. presence of perineural invasion, pT, etc). The nomograms were externally validated on a dataset of 109 patients who underwent STL in Ghent University Hospitals Ghent. Validation was performed using discrimination and calibration, evaluated by calibration plots. Results The nomograms based on postoperative variables performed better than the nomograms based on pre-operative variables, for all outcomes (OS: c = 0.68 vs 0.64; DFS: c=0.70 vs 0.64; DSS: c= 0.74 vs 0.64). The nomogram predicting DSS based on postoperative variables performed best (cfr Figure 1). C index for this nomogram on external validation was 0.65. As an example: ... |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| Relation: | https://biblio.ugent.be/publication/01H1144WJ3MWQ7YYAJ8TVGC6KM; http://hdl.handle.net/1854/LU-01H1144WJ3MWQ7YYAJ8TVGC6KM |
| الاتاحة: | https://biblio.ugent.be/publication/01H1144WJ3MWQ7YYAJ8TVGC6KM http://hdl.handle.net/1854/LU-01H1144WJ3MWQ7YYAJ8TVGC6KM |
| رقم الانضمام: | edsbas.CBC0C3B1 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |