التفاصيل البيبلوغرافية
| العنوان: |
Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results |
| المؤلفون: |
Astrid Herzum, Corrado Occella, Valerio Gaetano Vellone, Lodovica Gariazzo, Carlotta Pastorino, Jacopo Ferro, Angela Sementa, Katia Mazzocco, Nadia Vercellino, Gianmaria Viglizzo |
| المصدر: |
Diagnostics; Volume 13; Issue 14; Pages: 2380 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
spitz nevus, paediatric, multicomponent pattern, spitz dermoscopy, FISH |
| الوصف: |
Introduction: Spitzoid lesions are a wide tumour class comprising Spitz nevus (SN), atypical Spitz tumour (AST) and Spitz melanoma (SM). Materials and Methods: We conducted a single-centre-based retrospective survey on all histologically diagnosed spitzoid lesions of paediatric patients (1–18 years) of the last 10 years (2012–2022). Histopathological reports and electronic records of patients were used to retrieve relevant data regarding patients’ features, clinical and dermatoscopical aspects of lesions when recorded, and FISH tests when present. Results: Of 255 lesions, 82% were histologically benign, 17% atypical, 1% malignant. Clinically, 100% of SM were large (≥6 mm) and raised; AST were mainly large (63%), raised (98%), pink (95%). Small (≤5 mm), pigmented, flat lesions correlated with benign histology (respectively 90%, 97%, 98% SN) (p < 0.0001). Dermatoscopical patterns were analysed in 100 patients: starburst pattern correlated with benign histology (26% SN (p = 0.004)), while multicomponent pattern correlated with atypical/malignant lesions (56% AST, 50% SM (p = 0.0052)). Eighty-five lesions were subjected to fluorescence in situ hybridization (FISH): 34 (71% AST; 29% SN) were FISH-positive; 51 (63% SN; 37% AST) were FISH-negative (p = 0.0038). Discussion: This study confirmed predominant benign histology (82%) of paediatric spitzoid lesions, thus detecting 17% AST and 1% SM, highlighting the need for caution in handling spitzoid lesions. Conclusion: Until AST are considered potentially malignant proliferations and no reliable criteria are identified to distinguish them, the authors suggest a prudent approach, especially in children. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Pathology and Molecular Diagnostics; https://dx.doi.org/10.3390/diagnostics13142380 |
| DOI: |
10.3390/diagnostics13142380 |
| الاتاحة: |
https://doi.org/10.3390/diagnostics13142380 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.CB961342 |
| قاعدة البيانات: |
BASE |