Academic Journal
Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice
| العنوان: | Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice |
|---|---|
| المؤلفون: | Chiriță, Cornel, Ștefănescu, Emil, Zbârcea, Cristina E, Mireșan, Horațiu, Negreș, Simona, Nuță, Diana C, Limban, Carmen, Dănciulescu Miulescu, Rucsandra E, Marineci, Cristina D |
| المصدر: | Journal of Mind and Medical Sciences |
| بيانات النشر: | ValpoScholar |
| سنة النشر: | 2019 |
| المجموعة: | Valparaiso University: ValpoScholar |
| مصطلحات موضوعية: | doxepin, selegiline, antidepressant, pharmacological research, Behavioral Medicine, Psychiatric and Mental Health, Psychiatry |
| الوصف: | The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a synergism of action between a classical tricyclic antidepressant that inhibits noradrenalin and serotonin reuptake (doxepin), and a modern antidepressant that inhibits type-B monoamine oxidase (selegiline). We measured the antidepressant effect using the forced swimming test and the tail suspension test. We determined motor activity using the Activity Cage test. Our results have shown that the antidepressant effect intensifies significantly in the animals treated with both antidepressants simultaneously compared to those treated only with doxepin. Furthermore, we observed that selegiline decreases the sedative effect of doxepin in the Activity Cage test. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | https://scholar.valpo.edu/jmms/vol6/iss2/13; https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1199&context=jmms |
| الاتاحة: | https://scholar.valpo.edu/jmms/vol6/iss2/13 https://scholar.valpo.edu/cgi/viewcontent.cgi?article=1199&context=jmms |
| Rights: | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| رقم الانضمام: | edsbas.CB720D9F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |