Academic Journal

It is time to change thrombosis risk assessment for PV and ET?

التفاصيل البيبلوغرافية
العنوان: It is time to change thrombosis risk assessment for PV and ET?
المؤلفون: PASSAMONTI, FRANCESCO, Domenica Caramazza, Barbara Mora, Rosario Casalone, Margherita Maffioli
المساهمون: Passamonti, Francesco, Domenica, Caramazza, Barbara, Mora, Rosario, Casalone, Margherita, Maffioli
سنة النشر: 2014
المجموعة: IRIS UNIPV (Università degli studi di Pavia)
الوصف: Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms to be diagnosed according to the WHO classification. Molecular profiling must include the analysis of JAK2 (looking for the V617F point-mutation in PV and ET, screening exon 12 for mutations only in V617F-negative PV), CALR and MPL mutations (both in V617F-negative ET). The current risk stratification to predict thrombosis requires two parameters: age over 60 years and prior history of thrombosis. On the basis of these two risk factors patients can be stratified in low-risk and high-risk and receive a proper treatment. However, a modern stratification of thrombotic risk might consider "new" low-risk patients: conventional low-risk plus absence of leukocytosis from diagnosis onwards and a hematocrit level below 45% during the course of disease for PV; conventional low-risk plus absence of leukocytosis from diagnosis onwards, JAK2 negativity, CALR positivity, and absence of cardiovascular risk factors for ET.
نوع الوثيقة: article in journal/newspaper
وصف الملف: STAMPA
اللغة: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/25189723; volume:27; firstpage:121; lastpage:127; journal:BAILLIERE'S BEST PRACTICE IN CLINICAL HAEMATOLOGY; http://hdl.handle.net/11571/992396; http://www.ncbi.nlm.nih.gov/pubmed/?term=Francesco++Passamonti,Domenica++Caramazza,Barbara++Mora,Rosario++Casalone,Margherita++Maffioli
DOI: 10.1016/j.beha.2014.07.005
الاتاحة: http://hdl.handle.net/11571/992396
https://doi.org/10.1016/j.beha.2014.07.005
http://www.ncbi.nlm.nih.gov/pubmed/?term=Francesco++Passamonti,Domenica++Caramazza,Barbara++Mora,Rosario++Casalone,Margherita++Maffioli
رقم الانضمام: edsbas.CB59D8D2
قاعدة البيانات: BASE
الوصف
DOI:10.1016/j.beha.2014.07.005