Academic Journal
Retinal venular vessel diameters are smaller during ten days of bed rest
| العنوان: | Retinal venular vessel diameters are smaller during ten days of bed rest |
|---|---|
| المؤلفون: | Saloň, Adam, Çiftci, Göktuğ Mert, Zubac, Damir, Šimunič, Boštjan, Pišot, Rado, Narici, Marco, Fredriksen, Per Morten, Nkeh-Chungag, Benedicta Ngwenchi, Sourij, Harald, Šerý, Omar, Schmid-Zalaudek, Karin, Steuber, Bianca, De Boever, Patrick, Goswami, Nandu |
| المصدر: | 7 ; 13 ; Scientific Reports ; 1 |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | bed rest, retinal vessel analysis, retinal arteriolar, venular diameters, VDP::Medisinske Fag: 700 |
| الوصف: | Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight. This study investigates changes in retinal microcirculation during a ten-day bed rest protocol. Ten healthy young males (22.9 ± 4.7 years; body mass index: 23.6 ± 2.5 kg·m–2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a significant decrease in retinal venular diameter was observed, indicated by a significantly lower central retinal vein equivalent (from 226.1 µm, CI 8.90, to 211.4 µm, CI 8.28, p = .026), while no significant changes in central retinal artery equivalent were noted. Prolonged bed rest confinement resulted in a significant (up to 6.5%) reduction in retinal venular diameter. These findings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and reflect overall (cardio)-vascular deconditioning. ; publishedVersion |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Scientific Reports. 2023, 13 (1), .; https://hdl.handle.net/11250/3121638; cristin:2201787 |
| DOI: | 10.1038/s41598-023-46177-x |
| الاتاحة: | https://hdl.handle.net/11250/3121638 https://doi.org/10.1038/s41598-023-46177-x |
| Rights: | Navngivelse 4.0 Internasjonal ; http://creativecommons.org/licenses/by/4.0/deed.no ; © Te Author(s) 2023 |
| رقم الانضمام: | edsbas.CB4D5113 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-023-46177-x |
|---|