Academic Journal
Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis. Mol Pharmacol
| العنوان: | Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis. Mol Pharmacol |
|---|---|
| المؤلفون: | Carsten Culmsee, Norbert Gerling, Stefan L, Bianca Rickerts, Kazuo Umezawa, Josef Krieglstein |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | http://molpharm.aspetjournals.org/content/68/4/1006.full.pdf. |
| سنة النشر: | 2005 |
| المجموعة: | CiteSeerX |
| الوصف: | Our previous results showed that inhibition of protein tyrosine phosphatases (PTP) by orthovanadate is an appropriate strat-egy to mimic nerve growth factor (NGF) effects in neurons, including enhanced phosphorylation of TrkA, stimulation of downstream survival signaling pathways, and protection against apoptotic stress. In this study, we wanted to trigger such NGF-like survival signaling in primary hippocampal neu-rons with the more specific PTP inhibitors ethyl-3,4-dephosta-tin (DPN), 4-O-methyl-ethyl-3,4-dephostatin (Me-DPN), and methoxime-3,4-dephostatin. It was striking that only the nitric oxide (NO)-releasing dephostatin analogs DPN and Me-DPN, but not the nitrosamine-free methoxime derivative (which did not release NO), enhanced TrkA phosphorylation and protected the neurons against staurosporine (STS)-induced apoptosis. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1029.4085; http://molpharm.aspetjournals.org/content/68/4/1006.full.pdf |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1029.4085 http://molpharm.aspetjournals.org/content/68/4/1006.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.CB2B2BFE |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |