Academic Journal
AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts
| العنوان: | AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts |
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| المؤلفون: | Kato, Masaru, Ospelt, Caroline, Kolling, Christoph, Shimizu, Tomohiro, Kono, Michihito, Yasuda, Shinsuke, Michel, Beat A, Gay, Renate E, Gay, Steffen, Klein, Kerstin, Atsumi, Tatsuya |
| المصدر: | Kato, Masaru; Ospelt, Caroline; Kolling, Christoph; Shimizu, Tomohiro; Kono, Michihito; Yasuda, Shinsuke; Michel, Beat A; Gay, Renate E; Gay, Steffen; Klein, Kerstin; Atsumi, Tatsuya (2016). AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts. OncoTarget, 7(39):64221-64232. |
| بيانات النشر: | Impact Journals, LLC |
| سنة النشر: | 2016 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Rheumatology Clinic and Institute of Physical Medicine, 610 Medicine & health |
| الوصف: | Valosin containing protein (p97) is a chaperone implicated in a large number of biological processes including endoplasmic reticulum (ER)-associated protein degradation and autophagy. Silencing of p97 in rheumatoid arthritis (RA) synovial fibroblasts (RASFs) increased the amount of polyubiquitinated proteins, whereas silencing of its interaction partner histone deacetylase 6 (HDAC6) had no effect. Furthermore, silencing of p97 in RASFs increased not only rates of apoptotic cell death induced by TRAIL but also induced an autophagy-associated cell death during ER stress that was accompanied by the formation of polyubiquitinated protein aggregates and large vacuoles. Finally, we demonstrated an anti-arthritic effect of siRNAs targeting p97 in collagen-induced arthritis in rats. Our data indicate that p97 may be a new potential target in the treatment of RA. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1949-2553 |
| Relation: | https://www.zora.uzh.ch/id/eprint/126415/1/126415.pdf; info:pmid/27623077; urn:issn:1949-2553 |
| DOI: | 10.18632/oncotarget.11890 |
| الاتاحة: | https://www.zora.uzh.ch/id/eprint/126415/ https://www.zora.uzh.ch/id/eprint/126415/1/126415.pdf https://doi.org/10.18632/oncotarget.11890 |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 3.0 Unported (CC BY 3.0) ; http://creativecommons.org/licenses/by/3.0/ |
| رقم الانضمام: | edsbas.CB0AD5BA |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19492553 |
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| DOI: | 10.18632/oncotarget.11890 |