Academic Journal
Tenofovir alafenamide for prevention and treatment of hepatitis B virus reactivation and de novo hepatitis
| العنوان: | Tenofovir alafenamide for prevention and treatment of hepatitis B virus reactivation and de novo hepatitis |
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| المؤلفون: | Inada, Kento, Kaneko, Shun, Kurosaki, Masayuki, Yamashita, Koji, Kirino, Sakura, Osawa, Leona, Hayakawa, Yuka, Sekiguchi, Shuhei, Higuchi, Mayu, Takaura, Kenta, Maeyashiki, Chiaki, Tamaki, Nobuharu, Yasui, Yutaka, Itakura, Jun, Takahashi, Yuka, Tsuchiya, Kaoru, Nakanishi, Hiroyuki, Okamoto, Ryuichi, Izumi, Namiki |
| المساهمون: | Japan Agency for Medical Research and Development |
| المصدر: | JGH Open ; volume 5, issue 9, page 1085-1091 ; ISSN 2397-9070 2397-9070 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background and Aim Administration of tenofovir alafenamide (TAF) as prevention or treatment of hepatitis B virus (HBV) reactivation is not well known. The aim of this study is to reveal the efficacy and safety of TAF against HBV reactivation. Methods Entecavir (ETV) and TAF were given to 66 and 11 patients, respectively, as prophylaxis against or treatment of HBV reactivation during chemotherapy or immune suppression therapy from January 2010 to June 2020. The antiviral effects and safety were assessed. Results At week 24, the antiviral effects on patients receiving ETV and TAF were similar in terms of reduction of HBV DNA (−2.83 ± 1.45log IU/mL vs −3.05 ± 2.47log IU/mL; P = 0.857) and achieving undetectable levels of HBV DNA (78.8 vs 90.9%; P = 0.681). There was no significant difference in the decrease in the estimated glomerular filtration rate (eGFR) between the two groups (−0.62 ± 11.2 mL/min/1.73 m 2 vs −3.67 ± 13.2 mL/min/1.73 m 2 ; P = 0.291). Conclusion TAF is safe and effective against HBV reactivation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jgh3.12636 |
| الاتاحة: | http://dx.doi.org/10.1002/jgh3.12636 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jgh3.12636 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jgh3.12636 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.CB030F4B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jgh3.12636 |
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