Deletion of a coordinate regulator of type 2 cytokine expression in mice
| العنوان: | Deletion of a coordinate regulator of type 2 cytokine expression in mice |
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| المؤلفون: | Mohrs, Markus, Blankespoor, Catherine M., Wang, Zhi-En, Loots, Gaby G., Hadeiba, Husein, Shinkai, Kanade, Rubin, Edward M., Locksley, Richard M. |
| سنة النشر: | 2016 |
| المجموعة: | SciTec Connect (Office of Scientific and Technical Information - OSTI, U.S. Department of Energy) |
| مصطلحات موضوعية: | 59 BASIC BIOLOGICAL SCIENCES, CAPACITY, IMMUNITY, IN VITRO, IN VIVO, LYMPHOKINES, MAST CELLS, MICE, PATHOGENS |
| الوصف: | Mechanisms underlying the differentiation of stable T helper subsets will be important in understanding how discrete types of immunity develop in response to different pathogens. An evolutionarily conserved {approx}400 base pair non-coding sequence in the IL-4/IL-13 intergenic region, designated CNS-1, was deleted in mice. The capacity to develop Th2 cells was compromised in vitro and in vivo in the absence of CNS-1. Despite the profound effect in T cells, mast cells from CNS-1-deleted mice maintained their capacity to produce IL-4. A T cell-specific element critical for optimal expression of type 2 cytokines may represent evolution of a regulatory sequence exploited by adaptive immunity. |
| نوع الوثيقة: | other/unknown material |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | http://www.osti.gov/servlets/purl/836370; https://www.osti.gov/biblio/836370; https://doi.org/10.1038/ni0901-842 |
| DOI: | 10.1038/ni0901-842 |
| الاتاحة: | http://www.osti.gov/servlets/purl/836370 https://www.osti.gov/biblio/836370 https://doi.org/10.1038/ni0901-842 |
| رقم الانضمام: | edsbas.CADACAC2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ni0901-842 |
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