Academic Journal
Vitamin D and homocysteine in benign paroxysmal positional vertigo ; Витамин D и гомоцистеин при доброкачественном пароксизмальном позиционном головокружении
| العنوان: | Vitamin D and homocysteine in benign paroxysmal positional vertigo ; Витамин D и гомоцистеин при доброкачественном пароксизмальном позиционном головокружении |
|---|---|
| المؤلفون: | A. Bedenko S., L. Antonenko M., А. Беденко С., Л. Антоненко М. |
| المصدر: | Meditsinskiy sovet = Medical Council; № 2 (2022); 63-69 ; Медицинский Совет; № 2 (2022); 63-69 ; 2658-5790 ; 2079-701X |
| بيانات النشر: | REMEDIUM GROUP Ltd. |
| سنة النشر: | 2022 |
| المجموعة: | Medical Council (E-Journal) / Медицинский Совет |
| مصطلحات موضوعية: | endothelial dysfunction, benign paroxysmal positional vertigo, rotational vertigo, vitamin D, homocysteine, эндотелиальная дисфункция, доброкачественное пароксизмальное позиционное головокружение, вращательное головокружение, витамин D, гомоцистеин |
| الوصف: | Introduction. Benign paroxysmal positional vertigo (BPPV) is one of the most common causes of vertigo. Among the possible pathophysiological concepts, the largest evidence to date has been collected on the relationship of BPPV with a lack of vitamin D. Few studies have also been published on the assessment of factors of endothelial dysfunction (and, as a result, disturbances in the microcirculation of the inner ear) and BPPV. The problems of metabolic disorders in BPPV were still poorly highlighted in Russian sources.Objective. To investigate the levels of 25-OH-vitamin D and homocysteine among patients with BPPV and compare these factors depending on recurrence.Materials and methods. The study included 53 patients with BPPV, age 60 ± 12.6 (Me 62 [55; 68]), men accounted for 24.5%, women – 75.5%. All patients underwent a study of the neurological status and neurovestibularexamination, which included the Halmagi test, the head shake test, the Fukuda test, the Dix – Hallpike and McClure – Pagnini tests. Plasma 25-OH-vitamin D and homocysteine levels were assessed using enzyme-linked immunosorbent assay. The severity of vertigo was assessed using the dizziness handicap inventory (DHI).Results. The level of 25-OH vitamin D in with BPPV varied from 5.2 to 40 ng/ml, the average value was 19.53 ± 9.07 ng/ml, which corresponds to the deficit according to international recommendations (Me 17 [13; 24.8]). The level of 25-OH vitamin D in the group with recurrent BPPV was (Me 15 [12 and 22]), which was significantly lower than in the group with a single BPPV episode. The DHI score was significantly lower in the group with recurrent BPPV. There was a negative relationship between 25-OH-vitamin D levels and age, and a negative relationship between 25-OH-vitamin D and homocysteine in the DPPV group.Conclusion. There was a decrease in the level of 25-OH-vitamin D among patients with BPPV; in the group with recurrent BPPV, the level of 25-OH-vitamin D was significantly lower than in the group with a single dose of BPPV. The ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
| Relation: | https://www.med-sovet.pro/jour/article/view/6735/6078; Антоненко Л.М., Парфенов В.А. Специализированный подход к диагностике и лечению головокружения. Неврология, нейропсихиатрия, психосоматика. 2016;8(1):56–60. https://doi.org/10.14412/2074-2711-2016-1-56-60.; Popkirov S., Staab J.P., Stone J. Persistent postural-perceptual dizziness (PPPD): a common, characteristic and treatable cause of chronic dizziness. Pract Neurol. 2018;18(1):5–13. https://doi.org/10.1136/practneurol-2017-001809.; Chen J., Zhang S., Cui K., Liu C. Risk factors for benign paroxysmal positional vertigo recurrence: a systematic review and meta-analysis. J Neurol. 2021;268(11):4117–4127. https://doi.org/10.1007/s00415-020-10175-0.; Кунельская Н.Л., Мокрышева Н.Г., Гусева А.Л., Байбакова Е.В., Манаенкова Е.А. Доброкачественное пароксизмальное позиционное головокружение: современные представления об этиологии и патогенезе. Вестник оториноларингологии. 2017;82(3):75–79. https://doi.org/10.17116/otorino201782375-79.; Беденко А.С., Антоненко Л.М., Баринов А.Н. Нарушения метаболизма в патогенезе различных причин головокружения и неустойчивости. Вестник Российской академии медицинских наук. 2020;75(6):605–608. https://doi.org/10.15690/vramn1244.; Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е., Дзеранова Л.К., Каронова Т.Л., Ильин А.В. и др. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых. Проблемы эндокринологии. 2016;62(4):60–84. https://doi.org/10.14341/probl201662460-84.; Yang B., Lu Y., Xing D., Zhong W., Tang Q., Liu J., Yang X. Association between serum vitamin D levels and benign paroxysmal positional vertigo: a systematic review and meta-analysis of observational studies. Eur Arch Otorhinolaryngol. 2020;277(1):169–177. https://doi.org/10.1007/s00405-019-05694-0.; Mikulec A.A., Kowalczyk K.A., Pfitzinger M.E., Harris D.A., Jackson L.E. Negative association between treated osteoporosis and benign paroxysmal positional vertigo in women. J Laryngol Otol. 2010;124(4):374–376. https://doi.org/10.1017/s002221510999209x.; Kim S.Y., Kim H.J., Min C., Choi H.G. Association between benign paroxysmal positional vertigo and osteoporosis: two nested case-control studies. Osteoporos Int. 2020;31(10):2017–2024. https://doi.org/10.1007/s00198-020-05478-x.; Jeong S.H., Kim J.S., Shin J.W., Kim S., Lee H., Lee A.Y. et al. Decreased serum vitamin D in idiopathic benign paroxysmal positional vertigo. J Neurol. 2013;260(3):832–838. https://doi.org/10.1007/s00415-012-6712-2.; Yang Z., Li J., Zhu Z., He J., Wei X., Xie M. Effect of vitamin D supplementation on benign paroxysmal positional vertigo recurrence: A meta-analysis. Sci Prog. 2021;104(2):368504211024569. https://doi.org/10.1177/00368504211024569.; Karataş A., Acar Yüceant G., Yüce T., Hacı C., Cebi I.T., Salviz M. Association of Benign Paroxysmal Positional Vertigo with Osteoporosis and Vitamin D Deficiency: A Case Controlled Study. J Int Adv Otol. 2017;13(2):259–265. https://doi.org/10.5152/iao.2016.2640.; Mpandzou G., Aït Ben Haddou E., Regragui W., Benomar A., Yahyaoui M. Vitamin D deficiency and its role in neurological conditions: A review. Rev Neurol (Paris). 2016;172(2):109–122. https://doi.org/10.1016/j.neurol.2015.11.005.; James E., Dobson R., Kuhle J., Baker D., Giovannoni G., Ramagopalan S.V. The effect of vitamin D-related interventions on multiple sclerosis relapses: a meta-analysis. Mult Scler. 2013;19(12):1571–1579. https://doi.org/10.1177/1352458513489756.; McLaughlin L., Clarke L., Khalilidehkordi E., Butzkueven H., Taylor B., Broadley S.A. Vitamin D for the treatment of multiple sclerosis: a meta-analysis. J Neurol. 2018;265(12):2893–2905. https://doi.org/10.1007/s00415-018-9074-6.; Büki B., Jünger H., Zhang Y., Lundberg Y.W. The Price of Immune Responses and the Role of Vitamin D in the Inner Ear. Otol Neurotol. 2019;40(6):701–709. https://doi.org/10.1097/mao.0000000000002258.; Goto F., Hayashi K., Kunihiro T., Ogawa K. The possible contribution of angiitis to the onset of benign paroxysmal positional vertigo (BPPV). Int Tinnitus J. 2010;16(1):25–28. Available at: https://pubmed.ncbi.nlm.nih.gov/21609909/.; Li J., Wu R., Xia B., Wang X., Xue M. Serum levels of superoxide dismutases in patients with benign paroxysmal positional vertigo. Biosci Rep. 2020;40(5):BSR20193917. https://doi.org/10.1042/bsr20193917.; Vibert D., Kompis M., Häusler R. Benign paroxysmal positional vertigo in older women may be related to osteoporosis and osteopenia. Ann Otol Rhinol Laryngol. 2003;112(10):885–889. https://doi.org/10.1177/000348940311201010.; Von Brevern M., Radtke A., Lezius F., Feldmann M., Ziese T., Lempert T., Neuhauser H. Epidemiology of benign paroxysmal positional vertigo: a population based study. J Neurol Neurosurg Psychiatry. 2007;78(7):710–715. https://doi.org/10.1136/jnnp.2006.100420.; Yu S., Liu F., Cheng Z., Wang Q. Association between osteoporosis and benign paroxysmal positional vertigo: a systematic review. BMC Neurol. 2014;14:110. https://doi.org/10.1186/1471-2377-14-110.; Lee S.B., Lee C.H., Kim Y.J., Kim H.M. Biochemical markers of bone turnover in benign paroxysmal positional vertigo. PLoS ONE. 2017;12(5):e0176011. https://doi.org/10.1371/journal.pone.0176011.; Zhang Z.Y., Tian S.F., Li H., Cao X.W., Song Y. The correlations between serum vitamin D, parathyroid hormone, and bone mineral density with benign paroxysmal positional vertigo. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019;33(6):504–507. (In Chinese) https://doi.org/10.13201/j.issn.1001-1781.2019.06.007.; AlGarni M.A., Mirza A.A., Althobaiti A.A., Al-Nemari H.H., Bakhsh L.S. Association of benign paroxysmal positional vertigo with vitamin D deficiency: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2018;275(11):2705–2711. https://doi.org/10.1007/s00405-018-5146-6.; Zhang Y.M., Yang Z.D., Li W.X., Shi C., Yu Y.F. The relationship between the recurrence of benign paroxysmal positional vertigo and the level of bone mineral as well as estrogen in postmenopausal women. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017;52(12):881–884. (In Chinese) https://doi.org/10.3760/cma.j.issn.1673-0860.2017.12.001.; Дубченко Е.А., Иванов А.В., Бойко А.Н., Спирина Н.Н., Гусев Е.И., Кубатиев А.А. Гипергомоцистеинемия и эндотелиальная дисфункция при сосудистых и аутоиммунных заболеваниях головного мозга. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019;119(11):133–138. https://doi.org/10.17116/jnevro2019119111133.; Holmen M., Hvas A.M., Arendt J.F.H. Hyperhomocysteinemia and Ischemic Stroke: A Potential Dose-Response Association-A Systematic Review and Meta-analysis. TH Open. 2021;5(3):e420–e437. https://doi.org/10.1055/s-0041-1735978.; Raponi G., Teggi R., Gatti O., Giordano L., Bussi M. Postural control in patients after a recent vestibular neuritis with hyperhomocysteinemia. Indian J Otolaryngol Head Neck Surg. 2013;65(2):146–150. https://doi.org/10.1007/s12070-012-0610-x.; Lion A., Spada R.S., Bosser G., Gauchard G.C., Anello G., Bosco P. et al. Biological determinants of postural disorders in elderly women. Int J Neurosci. 2013;123(1):24–30. https://doi.org/10.3109/00207454.2012.722570.; Feng C., Tang N., Huang H., Zhang G., Qi X., Shi F. 25-Hydroxy vitamin D level is associated with total MRI burden of cerebral small vessel disease in ischemic stroke patients. Int J Neurosci. 2019;129(1):49–54. https://doi.org/10.1080/00207454.2018.1503182.; https://www.med-sovet.pro/jour/article/view/6735 |
| DOI: | 10.21518/2079-701X-2022-16-2-63-69 |
| الاتاحة: | https://www.med-sovet.pro/jour/article/view/6735 https://doi.org/10.21518/2079-701X-2022-16-2-63-69 |
| Rights: | Authors publishing their articles in this journal shall agree to the following:Authors reserve the copyright to the work and grant the journal a license to publish the work for the first time Creative Commons Attribution License (CC BY), which allows other persons to distribute this work with the obligatory preservation of references to the authors of the original work and the original publication in this journal.Authors reserve the right to conclude separate contractual arrangements regarding the non-exclusive distribution of the work version in the form published here (for example, posting it in the institute’s repository, publication in a book), with reference to its original publication in this journal.Authors have the right to post work on the Internet (for example, in the institute’s repository or personal website) before and during the process of considering it by this journal, as this can result in a productive discussion and more references to this work. ; Авторы, публикующие в данном журнале, соглашаются со следующим:Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License, которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в журнале.Авторы сохраняют право заключать отдельные контрактные договорённости, касающиеся не-эксклюзивного распространения версии работы в опубликованном виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию.Авторы имеют право размещать работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу. (См. The Effect of Open Access). |
| رقم الانضمام: | edsbas.CAD15ABA |
| قاعدة البيانات: | BASE |
| DOI: | 10.21518/2079-701X-2022-16-2-63-69 |
|---|