Academic Journal
Serum soluble CD163 and interleukin-6 levels in women with ovarian endometriomas
| العنوان: | Serum soluble CD163 and interleukin-6 levels in women with ovarian endometriomas |
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| المؤلفون: | Jee, Byung Chul, Suh, Chang Suk, Kim, Seok Hyun, Moon, Shin Yong |
| المساهمون: | 지병철, 서창석, 김석현, 문신용 |
| بيانات النشر: | Karger |
| سنة النشر: | 2008 |
| المجموعة: | Seoul National University: S-Space |
| مصطلحات موضوعية: | Adult, Antigens, CD/*blood, Differentiation, Myelomonocytic/*blood, Biological Markers/blood, CA-125 Antigen/blood, Endometriosis/*blood, Enzyme-Linked Immunosorbent Assay, Female, Humans, Interleukin-16/*blood, Middle Aged, Ovarian Diseases/*blood, Receptors, Cell Surface/*blood |
| الوصف: | BACKGROUND: CD163 is a hemoglobin scavenger receptor exclusively expressed in the monocyte-macrophage system and its soluble form (sCD163) has not yet been studied as a serum marker in women with endometriosis. The purpose of this study was to evaluate whether serum levels of sCD163 and interleukin-6 (IL-6) could be possible markers for ovarian endometriomas discriminating adnexal benign cystic tumors. METHODS: The concentrations of sCD163 and IL-6 were determined using commercial ELISA kits in frozen sera collected from 95 women prior to surgery for adnexal benign cystic tumors: 44 with ovarian endometriomas, 24 with mature cystic teratomas, 10 with mucinous cystadenomas, 8 with serous cystadenomas and 9 with parovarian cysts. Serum levels of CA-125 were also recorded preoperatively. The volume of cysts was evaluated in women with ovarian endometriomas. RESULTS: The serum levels of sCD163 and IL-6 were not significantly different among the women with various adnexal benign cystic tumors. In patients with endometriomas (n = 44), the levels were similar to those with nonendometriotic benign cystic tumors (n = 51): 3,431.7 +/- 343.9 vs. 3,231.0 +/- 391.7 ng/ml for sCD163 and 5.3 +/- 0.9 vs. 12.9 +/- 4.0 pg/ml for IL-6 (mean +/- SEM). No correlation was noted between serum levels of two markers with volume of endometriomas. CONCLUSION: Our findings suggest that serum levels of sCD163 as well as IL-6 are not useful markers for ovarian endometriomas. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | Gynecol Obstet Invest. 2008;66(1):47-52; 1423-002X (Electronic); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18311079; http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000119091&Ausgabe=234533&ProduktNr=223845&filename=000119091.pdf; http://hdl.handle.net/10371/68039 |
| DOI: | 10.1159/000119091 |
| الاتاحة: | http://hdl.handle.net/10371/68039 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18311079 http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=000119091&Ausgabe=234533&ProduktNr=223845&filename=000119091.pdf https://doi.org/10.1159/000119091 |
| رقم الانضمام: | edsbas.CAC0D768 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000119091 |
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