Academic Journal
γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection
| العنوان: | γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection |
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| المؤلفون: | Quintana, Juan F., Sinton, Matthew C., Chandrasegaran, Praveena, Lestari, Agatha Nabilla, Heslop, Rhiannon, Cheaib, Bachar, Ogunsola, John, Ngoyi, Dieudonne Mumba, Kuispond Swar, Nono-Raymond, Cooper, Anneli, Mabbott, Neil A., Coffelt, Seth B., MacLeod, Annette |
| المصدر: | Quintana , J F , Sinton , M C , Chandrasegaran , P , Lestari , A N , Heslop , R , Cheaib , B , Ogunsola , J , Ngoyi , D M , Kuispond Swar , N-R , Cooper , A , Mabbott , N A , Coffelt , S B & MacLeod , A 2023 , ' γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection ' , Nature Communications , vol. 14 , 5279 . https://doi.org/10.1038/s41467-023-40962-y |
| سنة النشر: | 2023 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| الوصف: | African trypanosomes colonise the skin to ensure parasite transmission. However, how the skin responds to trypanosome infection remains unresolved. Here, we investigate the local immune response of the skin in a murine model of infection using spatial and single cell transcriptomics. We detect expansion of dermal IL-17A-producing Vγ6+ cells during infection, which occurs in the subcutaneous adipose tissue. In silico cell-cell communication analysis suggests that subcutaneous interstitial preadipocytes trigger T cell activation via Cd40 and Tnfsf18 signalling, amongst others. In vivo, we observe that female mice deficient for IL-17A-producing Vγ6+ cells show extensive inflammation and limit subcutaneous adipose tissue wasting, independently of parasite burden. Based on these observations, we propose that subcutaneous adipocytes and Vγ6+ cells act in concert to limit skin inflammation and adipose tissue wasting. These studies provide new insights into the role of γδ T cell and subcutaneous adipocytes as homeostatic regulators of skin immunity during chronic infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://research.manchester.ac.uk/en/publications/e12a59f2-ef4d-4921-b694-100e871dc0e3 |
| DOI: | 10.1038/s41467-023-40962-y |
| الاتاحة: | https://research.manchester.ac.uk/en/publications/e12a59f2-ef4d-4921-b694-100e871dc0e3 https://doi.org/10.1038/s41467-023-40962-y |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.CA7DE8F6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-023-40962-y |
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