Academic Journal
Mechanism research of non‐coding RNA in immune checkpoint inhibitors therapy
| العنوان: | Mechanism research of non‐coding RNA in immune checkpoint inhibitors therapy |
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| المؤلفون: | Bian, Jie, Shao, Rui, Li, Juan, Zhu, Jing‐Feng, Shao, Ai‐Zhong, Liu, Chao, Lu, L. V., Pan, Hui‐Wen, Shi, Yi‐Jun, Fang, Na |
| المصدر: | Cancer Science ; volume 115, issue 11, page 3520-3531 ; ISSN 1347-9032 1349-7006 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Immune checkpoint inhibitor (ICI) therapies for tumors of different systems have attained significant achievements and have changed the current situation of tumor treatment due to their therapeutic characteristics of high specificity and low side effects. The immune checkpoint Programmed death 1/Programmed cell death‐Ligand 1 (PD‐1/PD‐L1) axis exerts a vital role in the immune escape of tumor cells. As a result, it has become a key target for tumor immunotherapy. Therefore, to perfect research into potential regulatory factors for the PD‐1/PD‐L1 axis, in order to understand and illustrate tumor ICI therapy mechanisms, is a significant goal. Moreover, ncRNA has been verified to regulate the PD‐1/PD‐L1 axis in the tumor immune microenvironment to regulate tumor genesis and development. ncRNAs can improve or decrease the efficacy of ICI therapy by modulating PD‐L1 expression. This review aimed to investigate the mechanisms of action of ncRNA in regulating the PD‐1/PD‐L1 axis in ICI therapy, to provide more efficient immunotherapy for tumors of different systems. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/cas.16309 |
| الاتاحة: | http://dx.doi.org/10.1111/cas.16309 https://onlinelibrary.wiley.com/doi/pdf/10.1111/cas.16309 |
| Rights: | http://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.CA703EA3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/cas.16309 |
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