Academic Journal
Aortic aneurysms, chronic kidney disease and metalloproteinases
| العنوان: | Aortic aneurysms, chronic kidney disease and metalloproteinases |
|---|---|
| المؤلفون: | Andreucci M., Provenzano M., Faga T., Michael A., Patella G., Mastroroberto P., Serraino G. F., Bracale U. M., Ielapi N., Serra R. |
| المساهمون: | Andreucci, M., Provenzano, M., Faga, T., Michael, A., Patella, G., Mastroroberto, P., Serraino, G. F., Bracale, U. M., Ielapi, N., Serra, R. |
| سنة النشر: | 2021 |
| المجموعة: | IRIS Università degli Studi di Napoli Federico II |
| مصطلحات موضوعية: | Aneurysm expansion, Cardiovascular risk, EGFR, End-stage kidney disease, Extracellular matrix, MP, Proteinuria, Renal tubular injury |
| الوصف: | Metalloproteinases (MPs) are proteolytic enzymes involved in extracellular matrix deposi-tion, regulation of cellular signals of inflammation, proliferation, and apoptosis. Metalloproteinases are classified into three families: Matrix-MPs (MMPs), A-Disintegrin-and-Metalloprotease (ADAMs), and the A-Disintegrin-and-Metalloproteinase-with-Thrombospondin-1-like-Domains (ADAMTS). Previous studies showed that MPs are involved in the development of aortic aneurysms (AA) and, concomitantly, in the onset of chronic kidney disease (CKD). CKD has been, per se, associated with an increased risk for AA. The aim of this review is to examine the pathways that may associate MPs with CKD and AA. Several MMPs, such as MMP-2,-8,-9, and TIMP-1 have been shown to damage the AA wall and to have a toxic effect on renal tubular cells, leading to fibrosis. Similarly, ADAM10 and 17 have been shown to degrade collagen in the AA wall and to worsen kidney function via pro-inflammatory stimuli, the impairment of the Renin-Angiotensin-Aldosterone System, and the degradation of structural proteins. Moreover, MMP-2 and-9 inhibitors reduced aneurysm growth and albuminuria in experimental and human studies. It would be important, in the future, to expand research on MPs from both a prognostic, namely, to refine risk stratification in CKD patients, and a predictive perspective, likely to improve prognosis in response to targeted treatments. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000622117700001; volume:11; issue:2; firstpage:1; lastpage:13; numberofpages:13; journal:BIOMOLECULES; http://hdl.handle.net/11588/837212; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85100006452 |
| DOI: | 10.3390/biom11020194 |
| الاتاحة: | http://hdl.handle.net/11588/837212 https://doi.org/10.3390/biom11020194 |
| رقم الانضمام: | edsbas.CA3D2A97 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/biom11020194 |
|---|