Academic Journal
EBV Encoded RNA �뼇�꽦 �쐞�븫�뿉�꽌 EBV Latent Membrane Protein 1 �쑀�쟾�옄 蹂��솕�� TGF-棺1, TGF-棺RII, p21,p16, E2F1, Thymidylate Synthase 諛� NF-觀B �떒諛� 諛쒗쁽�뿉 ���븳 硫댁뿭議곗쭅�솕�븰�쟻 �뿰援� ; Genetic Analysis of EBV-LMP1 and Immunohistochemical Expression of TGF-棺1, TGF-棺RII, p21, p16, E2F1, Thymidylate Synthase, and NF-觀B in EBV Encoded RNA-positive Gastric Adenocarcinoma
| العنوان: | EBV Encoded RNA �뼇�꽦 �쐞�븫�뿉�꽌 EBV Latent Membrane Protein 1 �쑀�쟾�옄 蹂��솕�� TGF-棺1, TGF-棺RII, p21,p16, E2F1, Thymidylate Synthase 諛� NF-觀B �떒諛� 諛쒗쁽�뿉 ���븳 硫댁뿭議곗쭅�솕�븰�쟻 �뿰援� ; Genetic Analysis of EBV-LMP1 and Immunohistochemical Expression of TGF-棺1, TGF-棺RII, p21, p16, E2F1, Thymidylate Synthase, and NF-觀B in EBV Encoded RNA-positive Gastric Adenocarcinoma |
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| المساهمون: | Cho Mee-Yon, Eom Min-seob, Park Kwang-Hwa, Kim Mee-Dong, Sung Seung-Hoon, Kim Myoung-Soo, Kim Dae-Sung, Choi Sun-Ju, Kim, Myoung Soo |
| المصدر: | T200603808.pdf |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | Stomach neoplasms, Epstein-Barr virus, EBV-Associated Membrane Antigen, Protein p16 |
| الوصف: | Background : Although clinicopathologic differences have been described between Epstein- Barr virus (EBV)-positive and negative gastric adenocarcinomas, the pathogenetic basis for these differences remains unclear. In this study, efforts were made to confirm that expression of EBV-latent membrane protein (LMP1) and immunohistochemical characteristics of EBVpositive gastric adenocarcinomas. Methods : We investigated genomic deletion, and RNA & protein expression of the EBV-LMP1, as well as immunohistochemical protein expression of transforming growth factor (TGF)-棺1, TGF-棺RII, p21, p16, E2F1, thymidylate synthase, and NF-觀B in relation to EBV positive gastric adenocarcinoma. Results : A total of 38 Epstein-Barr Virus Encoded RNA-positive and 80 negative gastric carcinomas were examined. A 30 bp DNA deletion in the EBV-LMP1 gene, initiating at codon 342, was detected in 94.4% of EBVpositive cases. By RT-PCR and western blotting, EBV-LMP1 mRNA and protein expressions were absent in all cases, re- gardless of DNA deletion. No significant differences in TGF-棺1, TGF-棺RII, p21, NF-觀B, E2F1, or thymidylate synthase expression were identified. However, the decreased expression of p16 was found in 84.2% of EBV-positive carcinomas, relative to only 57.5% of EBV-negative tumors (p=0.024). Conclusion : EBV-LMP1 DNA deletion, mRNA and protein losses are highly prevalent in EBV-positive gastric adenocarcinoma among Korean patients, along with decreased p16 expression. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 176~184 |
| اللغة: | unknown |
| تدمد: | 1738-1843 2092-8920 |
| Relation: | KOREAN JOURNAL OF PATHOLOGY; J02092; OAK-2006-02160; https://ir.ymlib.yonsei.ac.kr/handle/22282913/110900; T200603808; KOREAN JOURNAL OF PATHOLOGY , Vol.40(3) : 176-184, 2006; 55604 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/110900 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; free |
| رقم الانضمام: | edsbas.CA243F17 |
| قاعدة البيانات: | BASE |
| تدمد: | 17381843 20928920 |
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