Academic Journal
Effect of chlorhexidine bathing on colonization or infection with Acinetobacter baumannii: a systematic review and meta-analysis
| العنوان: | Effect of chlorhexidine bathing on colonization or infection with Acinetobacter baumannii: a systematic review and meta-analysis |
|---|---|
| المؤلفون: | Fan, C. Y., Lee, W. T., Hsu, T. C., Lee, C. H., Wang, S. P., Chen, W. S., Huang, C. H., Lee, C. C. |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2019 |
| المجموعة: | The University of Queensland: UQ eSpace |
| مصطلحات موضوعية: | Chlorhexidine, Drug-resistant Acinetobacter baumannii, Short-course therapy, Treatment duration, 2725 Infectious Diseases, 2726 Microbiology (medical) |
| الوصف: | Healthcare-associated infections (HAIs) caused by multi-drug-resistant Gram-negative bacteria (MDRGNB) have increased prevalence in intensive care units (ICUs). A common strategy to prevent HAIs is bathing patients with chlorhexidine gluconate (CHG). However, the effectiveness of CHG bathing against multidrug-resistant Acinetobacter baumannii (MDRAB) is still controversial. The aim of this study was to perform a systematic review and meta-analysis of the effectiveness of CHG bathing on Acinetobacter baumannii colonization and infection in the ICU setting. A systematic literature search of PubMed, EMBASE, Web of Science and CINAHL was performed from inception through to June 2018. Randomized controlled trials (RCTs), pre-post studies, or interrupted time series (ITS) studies were included. The numbers of patients with/without colonization or infection of A. baumannii in the experimental or control groups were extracted from each study. Quality assessment was performed by the related instruments of National Institute of Health. Pooled risk ratios (RRs) were calculated using the random-effects model. One RCT and 12 pre-post or ITS studies comprising 18,217 patients were included, of which 8069 were in the CHG bathing arm and 9051 in the control arm. CHG bathing was associated with a reduced colonization of A. baumannii (RR, 0.66; 95% confidence interval: 0.57–0.77; P |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1532-2939 0195-6701 |
| Relation: | 104-2314-B-002 -039 -MY3 |
| الاتاحة: | https://espace.library.uq.edu.au/view/UQ:bc64e15 |
| رقم الانضمام: | edsbas.C9E0F5AB |
| قاعدة البيانات: | BASE |
| تدمد: | 15322939 01956701 |
|---|