Academic Journal
NICO Phase II clinical trial - focus on an emerging immunotherapy strategy for the adjuvant treatment of locally-advanced oral cancers
| العنوان: | NICO Phase II clinical trial - focus on an emerging immunotherapy strategy for the adjuvant treatment of locally-advanced oral cancers |
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| المؤلفون: | Brooker, RC, Schache, AG, Sacco, JJ |
| بيانات النشر: | Elsevier BV |
| سنة النشر: | 2021 |
| المجموعة: | The University of Liverpool Repository |
| الوصف: | Outcomes remain poor for patients presenting with locally-advanced oral cancers and it remains imperative to re-evaluate adjuvant therapies to provide improved outcomes, ideally without compromising on long-term quality of life. We present current available evidence that supports the use of immune checkpoint inhibitors (ICI) in squamous cell carcinoma (SCC) of the head and neck and discuss trials examining the integration of ICI into the locoregional management of such lesions that are resectable. We focus particularly on the Neoadjuvant and adjuvant nivolumab as Immune Checkpoint inhibition in Oral cavity cancer (NICO) trial which is investigating the integration of neoadjuvant and adjuvant ICI into the treatment of resectable locally-advanced oral cavity cancers. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | http://livrepository.liverpool.ac.uk/3101657/1/Brooker%202020%20BJOMS_NICO%20short%20communication.pdf; Brooker, RC orcid:0000-0002-0668-6889 , Schache, AG orcid:0000-0001-9466-6038 and Sacco, JJ (2021) NICO Phase II clinical trial - focus on an emerging immunotherapy strategy for the adjuvant treatment of locally-advanced oral cancers. BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 59 (8). pp. 959-962. |
| DOI: | 10.1016/j.bjoms.2020.08.059 |
| الاتاحة: | http://livrepository.liverpool.ac.uk/3101657/ https://doi.org/10.1016/j.bjoms.2020.08.059 http://livrepository.liverpool.ac.uk/3101657/1/Brooker%202020%20BJOMS_NICO%20short%20communication.pdf |
| رقم الانضمام: | edsbas.C9C619EF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.bjoms.2020.08.059 |
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