Academic Journal
CD14 is a key organizer of microglial responses to CNS infection and injury
| العنوان: | CD14 is a key organizer of microglial responses to CNS infection and injury |
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| المؤلفون: | Janova, Hana, Böttcher, Chotima, Holtman, Inge R., Regen, Tommy, Rossum, Denise van, Götz, Alexander, Ernst, Anne-Sophie, Fritsche, Christin, Gertig, Ulla, Saiepour, Nasrin, Gronke, Konrad, Wrzos, Claudia, Ribes, Sandra, Rolfes, Simone, Weinstein, Jonathan, Ehrenreich, Hannelore, Pukrop, Tobias, Kopatz, Jens, Stadelmann, Christine, Salinas-Riester, Gabriela, Weber, Martin S., Prinz, Marco, Brück, Wolfgang, Eggen, Bart J. L., Boddeke, Hendrikus W. G. M., Priller, Josef, Hanisch, Uwe-Karsten |
| المساهمون: | Janova, Hana, Böttcher, Chotima, Holtman, Inge R., Regen, Tommy, Rossum, Denise van, Götz, Alexander, Ernst, Anne-Sophie, Fritsche, Christin, Gertig, Ulla, Saiepour, Nasrin, Gronke, Konrad, Wrzos, Claudia, Ribes, Sandra, Rolfes, Simone, Weinstein, Jonathan, Ehrenreich, Hannelore, Pukrop, Tobias, Kopatz, Jens, Stadelmann, Christine, Salinas-Riester, Gabriela, Weber, Martin S., Prinz, Marco, Brück, Wolfgang, Eggen, Bart J. L., Boddeke, Hendrikus W. G. M., Priller, Josef, Hanisch, Uwe-Karsten |
| سنة النشر: | 2016 |
| المجموعة: | Georg-August-Universität Göttingen: GoeScholar |
| الوصف: | Microglia, innate immune cells of the CNS, sense infection and damage through overlapping receptor sets. Toll-like receptor (TLR) 4 recognizes bacterial lipopolysaccharide (LPS) and multiple injury-associated factors. We show that its co-receptor CD14 serves three non-redundant functions in microglia. First, it confers an up to 100-fold higher LPS sensitivity compared to peripheral macrophages to enable efficient proinflammatory cytokine induction. Second, CD14 prevents excessive responses to massive LPS challenges via an interferon β-mediated feedback. Third, CD14 is mandatory for microglial reactions to tissue damage-associated signals. In mice, these functions are essential for balanced CNS responses to bacterial infection, traumatic and ischemic injuries, since CD14 deficiency causes either hypo- or hyperinflammation, insufficient or exaggerated immune cell recruitment or worsened stroke outcomes. While CD14 orchestrates functions of TLR4 and related immune receptors, it is itself regulated by TLR and non-TLR systems to thereby fine-tune microglial damage-sensing capacity upon infectious and non-infectious CNS challenges. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://resolver.sub.uni-goettingen.de/purl?gro-2/7166; 3150405 |
| DOI: | 10.1002/glia.22955 |
| الاتاحة: | https://resolver.sub.uni-goettingen.de/purl?gro-2/7166 https://doi.org/10.1002/glia.22955 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C9C4ABCC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/glia.22955 |
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