Academic Journal
Long-term gastrointestinal sequelae in colon cancer survivors:prospective pilot study on identification, the need for clinical evaluation and effects of treatment
| العنوان: | Long-term gastrointestinal sequelae in colon cancer survivors:prospective pilot study on identification, the need for clinical evaluation and effects of treatment |
|---|---|
| المؤلفون: | Larsen, Helene M, Mekhael, Mira, Juul, Therese, Borre, Mette, Christensen, Peter, Mohr Drewes, Asbjørn, Thorlacius-Ussing, Ole, Laurberg, Søren, Krogh, Klaus, Ladefoged Fassov, Janne |
| المصدر: | Larsen , H M , Mekhael , M , Juul , T , Borre , M , Christensen , P , Mohr Drewes , A , Thorlacius-Ussing , O , Laurberg , S , Krogh , K , Ladefoged Fassov , J & Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Study Group 2021 , ' Long-term gastrointestinal sequelae in colon cancer survivors : prospective pilot study on identification, the need for clinical evaluation and effects of treatment ' , Colorectal Disease , vol. 23 , no. 2 , .... |
| سنة النشر: | 2021 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | bowel dysfunction, cancer survivors, colon cancer, gastrointestinal sequelae, late adverse effects |
| الوصف: | AIM: The aim of the present pilot study was to describe the type and frequency of long-term gastrointestinal symptoms within a well-defined cohort of colon cancer survivors, their wish for clinical evaluation and treatment outcomes. METHOD: A screening survey was sent to colon cancer survivors 12, 24 and 36 months after surgery. Based on their main symptoms, patients who wished to have a consultation were referred to the gastroenterological or surgical unit of our late cancer sequelae clinic. Treatment effect was monitored by questionnaires on bowel symptoms and the EuroQol five-dimensional (EQ-5D) quality-of-life score. RESULTS: Overall, 953 patients who had survived colon cancer received the screening survey and 767 replied (response rate 80.5%). Of these, 76 (9.9%; 95% CI 7.9%-12.2%) were referred for algorithm-based clinical evaluation and treatment of bowel dysfunction. The majority were women (69.7%) who had undergone a right-sided colonic resection (65.8%). Patients reported various symptoms, mainly including urgency, fragmented defaecation, loose stools and incontinence for liquid stools. Patients with emptying difficulties and low anterior resection syndrome-like symptoms were referred to the surgical unit and patients with diarrhoea were referred to the gastroenterological unit for clinical work-up. Our main endpoint, mean EQ-5D index after treatment, was improved compared with baseline (baseline 0.809, after treatment 0.846; p = 0.049). After treatment, self-rated bowel function and several bowel symptoms were improved as well. CONCLUSION: This study highlights the importance of identifying colon cancer survivors in need of treatment of late gastrointestinal sequelae and clinical management in a multidisciplinary team setting. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/codi.15544 |
| الاتاحة: | https://pure.au.dk/portal/en/publications/a0aa9e0e-c6c2-4c36-939f-c10ee675be50 https://doi.org/10.1111/codi.15544 http://www.scopus.com/inward/record.url?scp=85102403126&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.C9B53545 |
| قاعدة البيانات: | BASE |
| ResultId |
1 |
|---|---|
| Header |
edsbas BASE edsbas.C9B53545 849 3 Academic Journal academicJournal 848.9462890625 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.C9B53545&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://pure.au.dk/portal/en/publications/a0aa9e0e-c6c2-4c36-939f-c10ee675be50# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Long-term gastrointestinal sequelae in colon cancer survivors:prospective pilot study on identification, the need for clinical evaluation and effects of treatment
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Larsen%2C+Helene+M%22">Larsen, Helene M</searchLink><br /><searchLink fieldCode="AR" term="%22Mekhael%2C+Mira%22">Mekhael, Mira</searchLink><br /><searchLink fieldCode="AR" term="%22Juul%2C+Therese%22">Juul, Therese</searchLink><br /><searchLink fieldCode="AR" term="%22Borre%2C+Mette%22">Borre, Mette</searchLink><br /><searchLink fieldCode="AR" term="%22Christensen%2C+Peter%22">Christensen, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Mohr+Drewes%2C+Asbjørn%22">Mohr Drewes, Asbjørn</searchLink><br /><searchLink fieldCode="AR" term="%22Thorlacius-Ussing%2C+Ole%22">Thorlacius-Ussing, Ole</searchLink><br /><searchLink fieldCode="AR" term="%22Laurberg%2C+Søren%22">Laurberg, Søren</searchLink><br /><searchLink fieldCode="AR" term="%22Krogh%2C+Klaus%22">Krogh, Klaus</searchLink><br /><searchLink fieldCode="AR" term="%22Ladefoged+Fassov%2C+Janne%22">Ladefoged Fassov, Janne</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Larsen , H M , Mekhael , M , Juul , T , Borre , M , Christensen , P , Mohr Drewes , A , Thorlacius-Ussing , O , Laurberg , S , Krogh , K , Ladefoged Fassov , J & Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Study Group 2021 , ' Long-term gastrointestinal sequelae in colon cancer survivors : prospective pilot study on identification, the need for clinical evaluation and effects of treatment ' , Colorectal Disease , vol. 23 , no. 2 , .... ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2021 ) Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Aarhus University: Research ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22bowel+dysfunction%22">bowel dysfunction</searchLink><br /><searchLink fieldCode="DE" term="%22cancer+survivors%22">cancer survivors</searchLink><br /><searchLink fieldCode="DE" term="%22colon+cancer%22">colon cancer</searchLink><br /><searchLink fieldCode="DE" term="%22gastrointestinal+sequelae%22">gastrointestinal sequelae</searchLink><br /><searchLink fieldCode="DE" term="%22late+adverse+effects%22">late adverse effects</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => AIM: The aim of the present pilot study was to describe the type and frequency of long-term gastrointestinal symptoms within a well-defined cohort of colon cancer survivors, their wish for clinical evaluation and treatment outcomes. METHOD: A screening survey was sent to colon cancer survivors 12, 24 and 36 months after surgery. Based on their main symptoms, patients who wished to have a consultation were referred to the gastroenterological or surgical unit of our late cancer sequelae clinic. Treatment effect was monitored by questionnaires on bowel symptoms and the EuroQol five-dimensional (EQ-5D) quality-of-life score. RESULTS: Overall, 953 patients who had survived colon cancer received the screening survey and 767 replied (response rate 80.5%). Of these, 76 (9.9%; 95% CI 7.9%-12.2%) were referred for algorithm-based clinical evaluation and treatment of bowel dysfunction. The majority were women (69.7%) who had undergone a right-sided colonic resection (65.8%). Patients reported various symptoms, mainly including urgency, fragmented defaecation, loose stools and incontinence for liquid stools. Patients with emptying difficulties and low anterior resection syndrome-like symptoms were referred to the surgical unit and patients with diarrhoea were referred to the gastroenterological unit for clinical work-up. Our main endpoint, mean EQ-5D index after treatment, was improved compared with baseline (baseline 0.809, after treatment 0.846; p = 0.049). After treatment, self-rated bowel function and several bowel symptoms were improved as well. CONCLUSION: This study highlights the importance of identifying colon cancer survivors in need of treatment of late gastrointestinal sequelae and clinical management in a multidisciplinary team setting. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1111/codi.15544 ) Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://pure.au.dk/portal/en/publications/a0aa9e0e-c6c2-4c36-939f-c10ee675be50<br />https://doi.org/10.1111/codi.15544<br />http://www.scopus.com/inward/record.url?scp=85102403126&partnerID=8YFLogxK ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => info:eu-repo/semantics/restrictedAccess ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.C9B53545 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1111/codi.15544
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => bowel dysfunction
[Type] => general
)
[1] => Array
(
[SubjectFull] => cancer survivors
[Type] => general
)
[2] => Array
(
[SubjectFull] => colon cancer
[Type] => general
)
[3] => Array
(
[SubjectFull] => gastrointestinal sequelae
[Type] => general
)
[4] => Array
(
[SubjectFull] => late adverse effects
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Long-term gastrointestinal sequelae in colon cancer survivors:prospective pilot study on identification, the need for clinical evaluation and effects of treatment
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Larsen, Helene M
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mekhael, Mira
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Juul, Therese
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Borre, Mette
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Christensen, Peter
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mohr Drewes, Asbjørn
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Thorlacius-Ussing, Ole
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Laurberg, Søren
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Krogh, Klaus
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ladefoged Fassov, Janne
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Type] => published
[Y] => 2021
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-locals
[Value] => edsbas
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => $2
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |