Academic Journal
Long-term gastrointestinal sequelae in colon cancer survivors:prospective pilot study on identification, the need for clinical evaluation and effects of treatment
| العنوان: | Long-term gastrointestinal sequelae in colon cancer survivors:prospective pilot study on identification, the need for clinical evaluation and effects of treatment |
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| المؤلفون: | Larsen, Helene M, Mekhael, Mira, Juul, Therese, Borre, Mette, Christensen, Peter, Mohr Drewes, Asbjørn, Thorlacius-Ussing, Ole, Laurberg, Søren, Krogh, Klaus, Ladefoged Fassov, Janne |
| المصدر: | Larsen , H M , Mekhael , M , Juul , T , Borre , M , Christensen , P , Mohr Drewes , A , Thorlacius-Ussing , O , Laurberg , S , Krogh , K , Ladefoged Fassov , J & Danish Cancer Society Centre for Research on Survivorship and Late Adverse Effects after Cancer in the Pelvic Organs Study Group 2021 , ' Long-term gastrointestinal sequelae in colon cancer survivors : prospective pilot study on identification, the need for clinical evaluation and effects of treatment ' , Colorectal Disease , vol. 23 , no. 2 , .... |
| سنة النشر: | 2021 |
| المجموعة: | Aarhus University: Research |
| مصطلحات موضوعية: | bowel dysfunction, cancer survivors, colon cancer, gastrointestinal sequelae, late adverse effects |
| الوصف: | AIM: The aim of the present pilot study was to describe the type and frequency of long-term gastrointestinal symptoms within a well-defined cohort of colon cancer survivors, their wish for clinical evaluation and treatment outcomes. METHOD: A screening survey was sent to colon cancer survivors 12, 24 and 36 months after surgery. Based on their main symptoms, patients who wished to have a consultation were referred to the gastroenterological or surgical unit of our late cancer sequelae clinic. Treatment effect was monitored by questionnaires on bowel symptoms and the EuroQol five-dimensional (EQ-5D) quality-of-life score. RESULTS: Overall, 953 patients who had survived colon cancer received the screening survey and 767 replied (response rate 80.5%). Of these, 76 (9.9%; 95% CI 7.9%-12.2%) were referred for algorithm-based clinical evaluation and treatment of bowel dysfunction. The majority were women (69.7%) who had undergone a right-sided colonic resection (65.8%). Patients reported various symptoms, mainly including urgency, fragmented defaecation, loose stools and incontinence for liquid stools. Patients with emptying difficulties and low anterior resection syndrome-like symptoms were referred to the surgical unit and patients with diarrhoea were referred to the gastroenterological unit for clinical work-up. Our main endpoint, mean EQ-5D index after treatment, was improved compared with baseline (baseline 0.809, after treatment 0.846; p = 0.049). After treatment, self-rated bowel function and several bowel symptoms were improved as well. CONCLUSION: This study highlights the importance of identifying colon cancer survivors in need of treatment of late gastrointestinal sequelae and clinical management in a multidisciplinary team setting. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/codi.15544 |
| الاتاحة: | https://pure.au.dk/portal/en/publications/a0aa9e0e-c6c2-4c36-939f-c10ee675be50 https://doi.org/10.1111/codi.15544 http://www.scopus.com/inward/record.url?scp=85102403126&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.C9B53545 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/codi.15544 |
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