Academic Journal
The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia
| العنوان: | The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia |
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| المؤلفون: | Bager, Lucas Grove Vejlstrup, Petersen, Jeppe Kofoed, Havers-Borgersen, Eva, Resch, Timothy, Smolderen, Kim G., Mena-Hurtado, Carlos, Eiberg, Jonas, Køber, Lars, Fosbøl, Emil Loldrup |
| المصدر: | Bager , L G V , Petersen , J K , Havers-Borgersen , E , Resch , T , Smolderen , K G , Mena-Hurtado , C , Eiberg , J , Køber , L & Fosbøl , E L 2023 , ' The use of evidence-based medical therapy in patients with critical limb-threatening ischaemia ' , European Journal of Preventive Cardiology , vol. 30 , no. 11 , pp. 1092-1100 . https://doi.org/10.1093/eurjpc/zwad022 |
| سنة النشر: | 2023 |
| المجموعة: | University of Copenhagen: Research / Forskning ved Københavns Universitet |
| مصطلحات موضوعية: | Best medical therapy, Critical limb-threatening ischaemia, Evidence-based medical therapy, Guideline-recommended medical therapy, Myocardial infarction |
| الوصف: | Aims To describe the practice patterns of evidence-based medical therapy (EBM) and overall mortality in high-risk patients with critical limb-threatening ischaemia (CLTI), compared with patients with myocardial infarction (MI). Methods and results Using Danish registries, we identified patients 40–100 years of age with a first-time hospitalization for CLTI or MI from 2008–2018 and grouped them into CLTI, MI, and CLTI and history of MI (CLTI + MI). We examined the likelihood of filling prescriptions with EBM [i.e. antiplatelets (Aps), lipid-lowering agents (LLAs), angiotensin-converting enzyme inhibitor (ACEi), or angiotensin II-receptor blockers (ARBs)] within 3 months after discharge among survivors. Further, we assessed the adjusted 3-year mortality rates. We included 92 845 patients: 14 941 with CLTI (54.7% male), 74 830 with MI (64.6% male) and 3,074 with CLTI + MI (65.2% male). Patients with CLTI and CLTI + MI were older and had more comorbidities than patients with MI. Compared with patients with MI, the unadjusted odds ratios of filling prescriptions were 0.15 [confidence interval (CI): 0.14–0.15] for AP, 0.26 (CI: 0.25–0.27) for LLA, and 0.71 (CI: 0.69–0.74) for ARB/ACEi in patients with CLTI, and 0.22 (CI: 0.20–0.24) for AP, 0.38 (CI: 0.35–0.42) for LLA, and 1.17 (CI: 1.08–1.27) for ARB/ACEi in patients with CLTI + MI. Adjusted analyses showed similar results. Compared with patients with MI, adjusted 3-year hazard ratios for mortality were 1.69 (CI: 1.64–1.74) in patients with CLTI and 1.60 (CI: 1.51–1.69) in patients with CLTI + MI. Conclusion Patients with CLTI were undertreated with EBM and carried a more adverse prognosis, as compared with patients with MI, despite similar guidelines. ; Aims: To describe the practice patterns of evidence-based medical therapy (EBM) and overall mortality in high-risk patients with critical limb-threatening ischaemia (CLTI), compared with patients with myocardial infarction (MI). Methods and results: Using Danish registries, we identified patients 40-100 years of age ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1093/eurjpc/zwad022 |
| الاتاحة: | https://researchprofiles.ku.dk/da/publications/the-use-of-evidencebased-medical-therapy-in-patients-with-critical-limbthreatening-ischaemia(80bf9761-1a67-4bbc-ae99-38769f055c67).html https://doi.org/10.1093/eurjpc/zwad022 https://curis.ku.dk/ws/files/396094974/zwad022.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C9A81DFB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/eurjpc/zwad022 |
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