Academic Journal
High Plasma Levels of Soluble Endothelial Protein C Receptor Are Associated With Increased Mortality Among Children With Cerebral Malaria in Benin
| العنوان: | High Plasma Levels of Soluble Endothelial Protein C Receptor Are Associated With Increased Mortality Among Children With Cerebral Malaria in Benin |
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| المؤلفون: | Moussiliou, Azizath, Alao, Maroufou J., Denoeud-Ndam, Lise, Tahar, Rachida, Ezimegnon, Sem, Sagbo, Gratien, Amoussou, Annick, Luty, Adrian J.F., Deloron, Philippe, Tuikue Ndam, Nicaise |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2014 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | BRIEF REPORT |
| الوصف: | Loss of endothelial protein C receptor (EPCR) occurs at the sites of Plasmodium falciparum –infected erythrocyte sequestration in patients with or who died from cerebral malaria. In children presenting with different clinical syndromes of malaria, we assessed the relationships between endogenous plasma soluble EPCR (sEPCR) levels and clinical presentation or mortality. After adjustment for age, for treatment before admission, and for a known genetic factor, sEPCR level at admission was positively associated with cerebral malaria ( P = .011) and with malaria-related mortality ( P = .0003). Measuring sEPCR levels at admission could provide an early biological marker of the outcome of cerebral malaria. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| Relation: | http://jid.oxfordjournals.org/cgi/content/short/jiu661v2; http://dx.doi.org/10.1093/infdis/jiu661 |
| DOI: | 10.1093/infdis/jiu661 |
| الاتاحة: | http://jid.oxfordjournals.org/cgi/content/short/jiu661v2 https://doi.org/10.1093/infdis/jiu661 |
| Rights: | Copyright (C) 2014, Infectious Diseases Society of America |
| رقم الانضمام: | edsbas.C98F6DB2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/infdis/jiu661 |
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