Academic Journal
A 12‐month follow‐up study on the preventive effect of oral lansoprazole on acute exacerbation of chronic obstructive pulmonary disease
| العنوان: | A 12‐month follow‐up study on the preventive effect of oral lansoprazole on acute exacerbation of chronic obstructive pulmonary disease |
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| المؤلفون: | Xiong, Wei, Zhang, Quan‐san, Zhao, Wei, Ding, Wei, Liu, Jin‐ming, Zhao, Yun‐feng |
| المساهمون: | key department of health system of Pudong New Area, Shanghai, general programme of committee of science and technology of Pudong New Area, Shanghai |
| المصدر: | International Journal of Experimental Pathology ; volume 97, issue 2, page 107-113 ; ISSN 0959-9673 1365-2613 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2016 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Summary The objective of this study was to evaluate the preventive effects of oral administration of lansoprazole on acute exacerbation of chronic obstructive pulmonary disease ( COPD ). Patients with COPD in groups C and D in the stable phase were stratified into a group with neither gastroesophageal reflux nor lansoprazole therapy (group A) and a group subjected to oral lansoprazole therapy (group B 1 ) and a group not subjected to oral lansoprazole therapy (group B 2 ). The frequency scale for the symptoms of gastroesophageal reflux disease ( FSSG ) questionnaire, COPD assessment test (CAT) questionnaire, pulmonary function test and the 6‐minute walk test were applied; in addition, arterial blood gas, white blood cell ( WBC ), hs‐ CRP , liver function and the levels of IL ‐1β, IL ‐6, IL ‐8, TNF ‐α and GM ‐ CSF in sputum were monitored during follow‐up. In the 12‐month follow‐up period, the frequency of exacerbation in group B 2 was statistically higher than that in groups A and B 1 ( P < 0.05). After a 3‐month follow‐up, the score of groups A and B 1 in the FSSG questionnaire was significantly lower than that of group B 2 ( P < 0.05). After the 1‐year follow‐up, the CAT score, FEV 1 , 6‐min walk test, the total number of WBC , hs‐ CRP , alanine aminotransferase, aspartate aminotransferase, pH of the arterial blood, PaO 2 , Pa CO 2 and the levels of IL ‐1β, IL ‐6, IL ‐8, TNF ‐α and GM ‐ CSF in the sputum were statistically different in group B 2 compared with groups A and B 1 ( P < 0.05). Oral lansoprazole therapy decreased the frequency of acute exacerbation of COPD by alleviating gastroesophageal reflux and lowering the levels of IL ‐1β, IL ‐6, IL ‐8, TNF ‐α and GM ‐ CSF in the sputum. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/iep.12173 |
| الاتاحة: | http://dx.doi.org/10.1111/iep.12173 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fiep.12173 https://onlinelibrary.wiley.com/doi/pdf/10.1111/iep.12173 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.C98E9CBA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/iep.12173 |
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