Academic Journal
Defect of the endogenous inhibitory pain system in idiopathic restless legs syndrome: a laser evoked potentials study
| العنوان: | Defect of the endogenous inhibitory pain system in idiopathic restless legs syndrome: a laser evoked potentials study |
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| المؤلفون: | Antelmi, Elena, Squintani, Giovanna Maddalena, Sandri, Angela, Lippolis, Marianna, Segatti, Alessia, Tinazzi, Michele |
| المساهمون: | Antelmi, Elena, Squintani, Giovanna Maddalena, Sandri, Angela, Lippolis, Marianna, Segatti, Alessia, Tinazzi, Michele |
| سنة النشر: | 2023 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | laser evoked potentials, neurophysiology, pain system, restless legs syndrome |
| الوصف: | Background: Restless legs syndrome (RLS) is a complex sensorimotor disorder. Symptoms worsen toward evening and at rest and are temporarily relieved by movement. Symptoms are perceived as painful in up to 45% of cases, and nociception system may be involved. Objectives: To assess the descending diffuse noxious inhibitory control in RLS patients. Methods: Twenty-one RLS patients and twenty age and sex-matched healthy controls (HC) underwent a conditioned pain modulation protocol. Cutaneous heat stimuli were delivered via laser evoked potentials (LEPs) on the dorsum of the right hand (UL) and foot (LL). N2 and P2 latencies, N2/P2 amplitude and pain ratings (NRS) were recorded before (baseline), during, and after a heterotopic noxious conditioning stimulation (HNCS) application. The baseline/HNCS ratio was calculated for both UL and LL. Results: N2 and P2 latencies did not vary between groups at each condition and limbs. Both groups showed a physiological N2/P2 amplitude and NRS reduction during the HNCS condition in UL and LL in comparison to baseline and post conditions (all, P < 0.003). Between-groups comparisons revealed a significant lower amplitude reduction in RLS at the N2/P2 amplitude during the HNCS condition only for LL (RLS, 13.6 μV; HC, 10.1 μV; P = 0.004). Such result was confirmed by the significant difference at the ratio (RLS, 69%, HC, 52.5%; P = 0.038). Conclusions: The lower physiological reduction during the HNCS condition at LL in RLS patients suggests a defect in the endogenous inhibitory pain system. Further studies should clarify the causal link of this finding, also investigating the circadian modulation of this paradigm. © 2023 International Parkinson and Movement Disorder Society. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/37314385; info:eu-repo/semantics/altIdentifier/wos/WOS:001004844400001; volume:38; issue:9; firstpage:1688; lastpage:1696; numberofpages:9; journal:MOVEMENT DISORDERS; https://hdl.handle.net/11562/1096826; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85161853705; https://doi.org/10.1002/mds.29509 |
| DOI: | 10.1002/mds.29509 |
| الاتاحة: | https://hdl.handle.net/11562/1096826 https://doi.org/10.1002/mds.29509 |
| رقم الانضمام: | edsbas.C90AF922 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/mds.29509 |
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