Academic Journal
Economic evaluation of immune tolerance induction in children with severe hemophilia A and high-responding inhibitors : a cost-effectiveness analysis of prophylaxis with emicizumab
| العنوان: | Economic evaluation of immune tolerance induction in children with severe hemophilia A and high-responding inhibitors : a cost-effectiveness analysis of prophylaxis with emicizumab |
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| المؤلفون: | Camelo, Ricardo Mesquita, Barbosa, Mariana Michel, Araújo, Maiara Silva, Lúcio Muniz Jr, Roberto, Guerra Jr, Augusto Afonso, Godman, Brian, Rezende, Suely Meireles, Acurcio, Francisco de Assis, Martin, Antony P., Alvares-Teodoro, Juliana |
| سنة النشر: | 2023 |
| المجموعة: | University of Strathclyde Glasgow: Strathprints |
| مصطلحات موضوعية: | Pharmacy and materia medica |
| الوصف: | Objective: This study aimed to measure the cost-effectiveness of prophylaxis with emicizumab in PsHAhri on ITI in Brazil. Methods: A cost-effectiveness modeling analysis was used to estimate the costs per PsHAhri on ITI and the number of prevented bleedings from undertaking one intervention (prophylaxis with BpA) over another (prophylaxis with emicizumab), based on the Brazilian Ministry of Health perspective. Costs of ITI with recombinant FVIII, prophylaxis with BpA or emicizumab, and treated bleeding episodes with BpA costs were evaluated for PsHAhri who had ITI success or failure. This study was conducted with the perspective of the Brazilian Ministry of Health (payer). Results: During ITI, prophylaxis with BpA cost US $924 666/PsHAhri/ITI, whereas prophylaxis with emicizumab cost US $488 785/PsHAhri/ITI. During ITI, there was an average of 9.32 bleeding episodes/PsHAhri/ITI when BpA were used as prophylaxis and 0.67 bleeding/PsHAhri/ITI when emicizumab was used. By univariate deterministic sensitivity analysis, emicizumab remained dominant whichever variable was modified. Conclusion: In this study, prophylaxis with emicizumab during ITI is a dominant option compared with prophylaxis with BpA during ITI. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | unknown |
| Relation: | https://strathprints.strath.ac.uk/83425/1/Camelo_etal_VHRI_2022_Economic_evaluation_of_immune_tolerance_induction_in_children.pdf; Camelo, Ricardo Mesquita and Barbosa, Mariana Michel and Araújo, Maiara Silva and Lúcio Muniz Jr, Roberto and Guerra Jr, Augusto Afonso and Godman, Brian and Rezende, Suely Meireles and Acurcio, Francisco de Assis and Martin, Antony P. and Alvares-Teodoro, Juliana (2023 ) Economic evaluation of immune tolerance induction in children with severe hemophilia A and high-responding inhibitors : a cost-effectiveness analysis of prophylaxis with emicizumab. Value in Health Regional Issues , 34. pp. 31-39. ISSN 2212-1102 |
| DOI: | 10.1016/j.vhri.2022.10.007 |
| الاتاحة: | https://strathprints.strath.ac.uk/83425/ https://strathprints.strath.ac.uk/83425/1/Camelo_etal_VHRI_2022_Economic_evaluation_of_immune_tolerance_induction_in_children.pdf https://doi.org/10.1016/j.vhri.2022.10.007 |
| Rights: | cc_by_nc_nd |
| رقم الانضمام: | edsbas.C8C3CB76 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.vhri.2022.10.007 |
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