Academic Journal
Origins, Admixture Dynamics, and Homogenization of the African Gene Pool in the Americas
| العنوان: | Origins, Admixture Dynamics, and Homogenization of the African Gene Pool in the Americas |
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| المؤلفون: | Gouveia, Mateus H, Borda, Victor, Leal, Thiago P, Moreira, Rennan G, Bergen, Andrew W, Kehdy, Fernanda S G, Alvim, Isabela, Aquino, Marla M, Araujo, Gilderlanio S, Araujo, Nathalia M, Furlan, Vinicius, Liboredo, Raquel, Machado, Moara, Magalhaes, Wagner C S, Michelin, Lucas A, Rodrigues, Maíra R, Rodrigues-Soares, Fernanda, Sant Anna, Hanaisa P, Santolalla, Meddly L, Scliar, Marília O, Soares-Souza, Giordano, Zamudio, Roxana, Zolini, Camila, Bortolini, Maria Catira, Dean, Michael, Gilman, Robert H, Guio, Heinner, Rocha, Jorge, Pereira, Alexandre C, Barreto, Mauricio L, Horta, Bernardo L, Lima-Costa, Maria F, Mbulaiteye, Sam M, Chanock, Stephen J, Tishkoff, Sarah A, Yeager, Meredith, Tarazona-Santos, Eduardo |
| المساهمون: | Nielsen, Rasmus, National Institutes of Health, Center for Research on Genomics and Global Health, CRGGH, National Human Genome Research Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Center for Information Technology, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NCI, National Institute of Allergy, Infectious Diseases, Department of Health and Human Services |
| المصدر: | Molecular Biology and Evolution ; volume 37, issue 6, page 1647-1656 ; ISSN 0737-4038 1537-1719 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2020 |
| الوصف: | The Transatlantic Slave Trade transported more than 9 million Africans to the Americas between the early 16th and the mid-19th centuries. We performed a genome-wide analysis using 6,267 individuals from 25 populations to infer how different African groups contributed to North-, South-American, and Caribbean populations, in the context of geographic and geopolitical factors, and compared genetic data with demographic history records of the Transatlantic Slave Trade. We observed that West-Central Africa and Western Africa-associated ancestry clusters are more prevalent in northern latitudes of the Americas, whereas the South/East Africa-associated ancestry cluster is more prevalent in southern latitudes of the Americas. This pattern results from geographic and geopolitical factors leading to population differentiation. However, there is a substantial decrease in the between-population differentiation of the African gene pool within the Americas, when compared with the regions of origin from Africa, underscoring the importance of historical factors favoring admixture between individuals with different African origins in the New World. This between-population homogenization in the Americas is consistent with the excess of West-Central Africa ancestry (the most prevalent in the Americas) in the United States and Southeast-Brazil, with respect to historical-demography expectations. We also inferred that in most of the Americas, intercontinental admixture intensification occurred between 1750 and 1850, which correlates strongly with the peak of arrivals from Africa. This study contributes with a population genetics perspective to the ongoing social, cultural, and political debate regarding ancestry, admixture, and the mestizaje process in the Americas. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/molbev/msaa033 |
| DOI: | 10.1093/molbev/msaa033/33031937/msaa033.pdf |
| الاتاحة: | http://dx.doi.org/10.1093/molbev/msaa033 http://academic.oup.com/mbe/advance-article-pdf/doi/10.1093/molbev/msaa033/33031937/msaa033.pdf http://academic.oup.com/mbe/article-pdf/37/6/1647/33317000/msaa033.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.C8ABF8AF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/molbev/msaa033 |
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