التفاصيل البيبلوغرافية
| العنوان: |
Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV. |
| المؤلفون: |
Aljawharah Alrubayyi (9745763), Ester Gea-Mallorquí (9108077), Emma Touizer (11558140), Dan Hameiri-Bowen (11558143), Jakub Kopycinski (145112), Bethany Charlton (11558146), Natasha Fisher-Pearson (11558149), Luke Muir (5618948), Annachiara Rosa (9298421), Chloe Roustan (9556649), Christopher Earl (9760475), Peter Cherepanov (369), Pierre Pellegrino (208300), Laura Waters (4814466), Fiona Burns (324503), Sabine Kinloch (37369), Tao Dong (15551), Lucy Dorrell (79653), Sarah Rowland-Jones (74678), Laura E McCoy (10504190), Dimitra Peppa (125379) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry & Proteomics, Signalling & Oncogenes, Genome Integrity & Repair, Structural Biology & Biophysics, Cell Cycle & Chromosomes, Chemical Biology & High Throughput, Cherepanov FC001061, McDonald FC001115, SB |
| الوصف: |
There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that the majority of PLWH with ART suppressed HIV viral load, mount a detectable adaptive immune response to SARS-CoV-2. Humoral and SARS-CoV-2-specific T cell responses are comparable between HIV-positive and negative subjects and persist 5-7 months following predominately mild COVID-19 disease. T cell responses against Spike, Membrane and Nucleoprotein are the most prominent, with SARS-CoV-2-specific CD4 T cells outnumbering CD8 T cells. We further show that the overall magnitude of SARS-CoV-2-specific T cell responses relates to the size of the naive CD4 T cell pool and the CD4:CD8 ratio in PLWH. These findings suggest that inadequate immune reconstitution on ART, could hinder immune responses to SARS-CoV-2 with implications for the individual management and vaccine effectiveness in PLWH. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Characterization_of_humoral_and_SARS-CoV-2_specific_T_cell_responses_in_people_living_with_HIV_/16803247 |
| DOI: |
10.25418/crick.16803247.v1 |
| الاتاحة: |
https://doi.org/10.25418/crick.16803247.v1 |
| Rights: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.C8AA1E36 |
| قاعدة البيانات: |
BASE |