Academic Journal
Human Mesenchymal Stem Cells as a Carrier for a Cell-Mediated Drug Delivery
| العنوان: | Human Mesenchymal Stem Cells as a Carrier for a Cell-Mediated Drug Delivery |
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| المؤلفون: | Litvinova, L. S., Shupletsova, Valeria, Khaziakhmatova, O. G., Daminova, A. G., Kudryavtseva, V. L., Yurova, K. A., Malashchenko, V. V., Todosenko, Natalia, Popova, Valentina Aleksandrovna, Litvinov, R. I., Korotkova, Elena Ivanovna, Sukhorukov, Gleb, Gow, Andrew, Weissman, D., Atochina-Vasserman, E. N., Khlusov, Igor Albertovich |
| المصدر: | Frontiers in Bioengineering and Biotechnology |
| بيانات النشر: | Frontiers Media S. A. |
| سنة النشر: | 2022 |
| المجموعة: | Tomsk Polytechnic University (TPU): Electronic Archive / Томский политехнический университет: Электронный архив TPU |
| مصطلحات موضوعية: | стволовые клетки, жировые ткани, клеточная миграция, адресная доставка, микрокапсулы, лекарства, human adipose-derived mesenchymal stromal/stem cells, cell migration, target drug delivery, cellmediated drug delivery, synthetic microcapsules |
| الوصف: | A number of preclinical and clinical studies have demonstrated the efficiency of mesenchymal stromal cells to serve as an excellent base for a cell-mediated drug delivery system. Cell-based targeted drug delivery has received much attention as a system to facilitate the uptake a nd transfer of active substances to specific organs and tissues with high efficiency. Human mesenchymal stem cells (MSCs) are attracting increased interest as a promising tool for cell-based therapy due to their high proliferative capacity, multi-potency, and anti-inflammatory and immunomodulatory properties. In particular, these cells are potentially suitable for use as encapsulated drug transporters to sites of inflammation. Here, we studied the in vitro effects of incorporating synthetic polymer microcapsules at various microcapsule-to-cell ratios on the morphology, ultrastructure, cytokine profile, and migration ability of human adipose-derived MSCs at various time points post-phagocytosis. The data show that under appropriate conditions, human MSCs can be efficiently loaded with synthesized microcapsules without damaging the cell’s structural integrity with unexpressed cytokine secretion, retained motility, and ability to migrate through 8 ?m pores. Thus, the strategy of using human MSCs as a delivery vehicle for transferring microcapsules, containing bioactive material, across the tissue–blood or tumor–blood barriers to facilitate the treatment of stroke, cancer, or inflammatory diseases may open a new therapeutic perspective. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Frontiers in Bioengineering and Biotechnology. 2022. Vol. 10; Human Mesenchymal Stem Cells as a Carrier for a Cell-Mediated Drug Delivery / L. S. Litvinova, V. V. Shupletsova, O. G. Khaziakhmatova [et al.] // Frontiers in Bioengineering and Biotechnology. — 2022. — Vol. 10. — [796111, 14 p.].; http://earchive.tpu.ru/handle/11683/70707 |
| DOI: | 10.3389/fbioe.2022.796111 |
| الاتاحة: | http://earchive.tpu.ru/handle/11683/70707 https://doi.org/10.3389/fbioe.2022.796111 |
| Rights: | info:eu-repo/semantics/openAccess ; Attribution-NonCommercial 4.0 International ; https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.C8A75AAE |
| قاعدة البيانات: | BASE |
| DOI: | 10.3389/fbioe.2022.796111 |
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