Academic Journal
Nail Amyloidoma: Two Case Reports of a New Entity
| العنوان: | Nail Amyloidoma: Two Case Reports of a New Entity |
|---|---|
| المؤلفون: | Bonito, Frederico, Kolivras, Athanassios, Sass, Ursula, Richert, Bertrand |
| المصدر: | Skin Appendage Disorders |
| سنة النشر: | 2023 |
| المجموعة: | DI-fusion : dépôt institutionnel de l'Université libre de Bruxelles (ULB) |
| مصطلحات موضوعية: | Dermatologie, Amyloidoma, Amyloidosis, Localized amyloidosis, Nail disorder, Nodular amyloidosis |
| الوصف: | Introduction: Amyloidosis is a group of diseases characterized by extracellular deposits of abnormal insoluble proteins in different tissues. Amyloidoma is a localized tumoral deposit of amyloid in the absence of systemic amyloidosis, and it has been described in different anatomic sites. We report two cases of amyloidoma in the nail unit and provide insights into this recently described entity. Case Presentation: Both cases presented as an asymptomatic, slowly growing nodule underneath the distal nail bed of a toe with associated onycholysis. Histopathology was characterized in both patients by the presence of deposits of Congo red-positive, homogeneous, amorphous, and eosinophilic material within the dermis and subcutaneous tissue admixed with aggregates of plasma cells. In both cases, an extensive workup excluded systemic amyloidosis. Treatment was based on local excision, and no local recurrence or progression to systemic amyloidosis was observed at 1 year of follow-up. Conclusion: These are the first reports of amyloidomas of the nail unit. The clinical and histopathological presentations parallel those of an amyloidoma affecting the skin. Local excision seems to be an efficient treatment modality, but long-term follow-up is warranted in order to exclude recurrence, an associated marginal B-cell lymphoma, or progression to systemic amyloid L amyloidosis. ; SCOPUS: ar.j ; info:eu-repo/semantics/published |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| Relation: | uri/info:doi/10.1159/000529091; uri/info:scp/85149208975; https://dipot.ulb.ac.be/dspace/bitstream/2013/356492/3/Nailamyloidoma.pdf; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/356492 |
| الاتاحة: | http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/356492 https://dipot.ulb.ac.be/dspace/bitstream/2013/356492/3/Nailamyloidoma.pdf |
| رقم الانضمام: | edsbas.C873DA81 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |