Academic Journal
Antitumor and anti‐angiogenesis immunity induced by CR‐SEREX‐identified Xenopus RHAMM
| العنوان: | Antitumor and anti‐angiogenesis immunity induced by CR‐SEREX‐identified Xenopus RHAMM |
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| المؤلفون: | Yang, Han Shuo, Zhang, Dong Mei, Deng, Hong Xin, Peng, Feng, Wei, Yu Quan |
| المصدر: | Cancer Science ; volume 101, issue 4, page 862-868 ; ISSN 1347-9032 1349-7006 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2009 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Immunization with xenogeneic antigens is an attractive approach to induce cross‐reactive humoral and cellular immunity to inhibit tumor growth or angiogenesis. To identify novel xenogenic targets for immunotherapy, we have developed a modified serological expression cloning (SEREX) strategy, termed Cross‐reactive SEREX (CR‐SEREX). Among 78 positive clones identified by CR‐SEREX, Xenopus receptor for hyaluronic‐acid‐mediated motility (xRHAMM) was most frequently identified (18 times), indicating the strongest immunogenic potential for xenogenic immunotherapy. A DNA vaccine based on xRHAMM effectively induced a protective antitumor immunity against local tumor and lung metastasis in B16 melanoma mouse models. Angiogenesis was inhibited and cell apoptosis was increased within tumors. Antitumor activity of xRHAMM worked through stimulation of an antigen‐specific cellular response as well as through a specific humoral response against RHAMM, as confirmed by the depletion of immune cell subsets in vivo . Thus, a xenogenic vaccine based on xRHAMM induced an effective immunity against B16 melanoma cells and endothelial cells. ( Cancer Sci 2010; 101: 862–868) |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1349-7006.2009.01473.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1349-7006.2009.01473.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1349-7006.2009.01473.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1349-7006.2009.01473.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.C85FE75D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1349-7006.2009.01473.x |
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