Academic Journal
Circadian peculiarities of antioxidant and membrane-protective properties of glutargin in acute chrono-determined paracetamol-induced hepatitis ; Циркадианные особенности антиоксидантных и мембранопротекторных свойств глутаргина в условиях острого хронодетерминированного парацетамолового гепатита ; Циркадіанні особливості антиоксидантних та мембранопротекторних властивостей глутаргіну в умовах гострого хронодетермінованого парацетамолового гепатиту
| العنوان: | Circadian peculiarities of antioxidant and membrane-protective properties of glutargin in acute chrono-determined paracetamol-induced hepatitis ; Циркадианные особенности антиоксидантных и мембранопротекторных свойств глутаргина в условиях острого хронодетерминированного парацетамолового гепатита ; Циркадіанні особливості антиоксидантних та мембранопротекторних властивостей глутаргіну в умовах гострого хронодетермінованого парацетамолового гепатиту |
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| المؤلفون: | Kalko, K. O., Drogovoz, S. M., Koyro, O. O., Pozdniakova, A. Yu. |
| المصدر: | Clinical pharmacy; Vol. 21 No. 2 (2017); 46-52 ; Клиническая фармация; Том 21 № 2 (2017); 46-52 ; Клінічна фармація; Том 21 № 2 (2017); 46-52 ; 2518-1572 ; 1562-725X |
| بيانات النشر: | National University of Pharmacy |
| سنة النشر: | 2017 |
| المجموعة: | Clinical Pharmacy (E-Journal) / Клінічна фармація |
| مصطلحات موضوعية: | liver, circadian rhythm, hepatoprotectors, glutargin, UDC 615.451.16, 582.734.3, 581.45, печень, циркадианный ритм, гепатопротекторы, глутаргин, УДК 615.451.16, печінка, циркадіанний ритм, гепатопротектори, глутаргін |
| الوصف: | Hepatobiliary system diseases take a leading position among diseases of the gastrointestinal tract. One of the main groups of drugs used for their treatment is hepatoprotectors. Active development of chronophysiology, chronopatology and chronopharmacology creates the possibility of determining chronoportraits of drugs. Considering the latter it allows significantly optimizing the pharmacotherapy.Aim. To assess the circadian dependence of the antioxidant and membrane-protective activity of glutargin. The choice of the drug as the object of our study was made due to its frequent use in clinical practice.Materials and methods. The study was conducted on the model of acute paracetamol-induced hepatitis in the following chronosimulated mode: in the morning (09.00), in the daytime (15.00), in the evening (21.00) and at night (03.00). The dose of paracetamol in the experiment was 1000 mg/kg in rats. Glutargin was administered in the therapeutic and preventive mode in the dose of 135 mg/kg, i.e. an hour before administration of paracetamol and 2 hours after it.Results. The study conducted revealed the peculiarities of dysinchronosis of the prooxidant-antioxidant balance and the activity of cytolysis markers depending on the period of the day, in which paracetamol-induced hepatitis was simulated; it allowed determining the peculiarities of their correction with glutargin. The most distinct decrease in the AlAT and AsAT activity when using glutargin was observed against the background of night and day simulation of hepatitis. It is probably due to the circadian peculiarities of antioxidant and membrane-stabilizing properties of this drug.Conclusions. The circadian regulation peculiarities of prooxidant-antioxidant balance obtained with glutargin against the background of paracetamol-induced hepatitis should be considered when developing a comprehensive chronoportrait of this drug. ; Заболевания гепатобилиарной системы занимают лидирующие место среди заболеваний органов желудочно-кишечного тракта. Одной из основных групп ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Ukrainian |
| Relation: | http://cphj.nuph.edu.ua/article/view/cphj.17.1426/99530; http://cphj.nuph.edu.ua/article/view/cphj.17.1426 |
| DOI: | 10.24959/cphj.17.1426 |
| الاتاحة: | http://cphj.nuph.edu.ua/article/view/cphj.17.1426 https://doi.org/10.24959/cphj.17.1426 |
| Rights: | Copyright (c) 2017 National University of Pharmacy ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.C85AE981 |
| قاعدة البيانات: | BASE |
| DOI: | 10.24959/cphj.17.1426 |
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