Academic Journal
Copper(II) interaction with 3,5-diisopropylsalicylic acid (Dips): New insights on its role as a potential .OH inactivating ligand
| العنوان: | Copper(II) interaction with 3,5-diisopropylsalicylic acid (Dips): New insights on its role as a potential .OH inactivating ligand |
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| المؤلفون: | Brumas, Veronique, Miche, Helene, Fiallo, Marina |
| المساهمون: | Laboratoire de Chimie Bioinorganique Médicale (LCBM), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT), Centre Européen de Recherche et d'Enseignement des Géosciences de l'Environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0162-0134 ; Journal of Inorganic Biochemistry ; https://hal.science/hal-03897264 ; Journal of Inorganic Biochemistry, 2007, 101 (4), pp.565-577. ⟨10.1016/j.jinorgbio.2006.11.017⟩. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2007 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | Copper complexation, Inflammation, Salicylic acid derivatives, Copper-mediated oxidation, Anti-inflammatory agents, OH-inactivating ligand (OIL), Number of dissociable protons (NDP), Nonsteroidal anti-inflammatory drugs, NSAIDs, [CHIM]Chemical Sciences |
| الوصف: | International audience ; The purpose of this study was to identify the low-molar-mass complexes formed between copper(II) and 3,5-diisopropylsalic acid (Dips) in physiological conditions. Copper(II)-Dips complex equilibria were determined using glass electrode potentiometry and their solution structures checked by UV-visible spectrophotometry. Because of the low solubility of Dips in water, the equilibria were investigated in different water/ethanol mixtures. Formation constants were extrapolated to 100% water and then compared with the values obtained for the other anti-inflammatory drugs previously studied. Given the prime role of histidine as the copper(II) ligand in blood plasma, copper(II)-histidine-Dips ternary equilibria were studied under similar experimental conditions. Computer simulations of copper(II) distribution relative to different biofluids, gastrointestinal (g.i.) fluid and blood plasma, show that like salicylic and anthranilic acids, Dips favors g.i. copper absorption, but cannot exert any significant influence on plasma copper distribution. Moreover, Dips can mobilize increasing fractions of copper(II) as the pH decreases. In conclusion, Dips seems to correspond to the notion of .OH-inactivating ligand (OIL) as determined for anthranilic acid. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1016/j.jinorgbio.2006.11.017 |
| الاتاحة: | https://hal.science/hal-03897264 https://hal.science/hal-03897264v1/document https://hal.science/hal-03897264v1/file/Miche-CuHisDips-2007.pdf https://doi.org/10.1016/j.jinorgbio.2006.11.017 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.C856BC6E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.jinorgbio.2006.11.017 |
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