Academic Journal
A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: Result from a randomized study
| العنوان: | A nutrient cocktail prevents lipid metabolism alterations induced by 20 days of daily steps reduction and fructose overfeeding: Result from a randomized study |
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| المؤلفون: | Damiot, Anthony, Demangel, Rémi, Noone, John, Chery, Isabelle, Zahariev, Alexandre, Normand, Sylvain, Brioche, Thomas, Crampes, Francois, de Glisezinski, Isabelle, Lefai, Etienne, Bareille, Marie-Pierre, Chopard, A, Drai, Jocelyne, Collin-Chavagnac, Delphine, Heer, Martina, Gauquelin-Koch, Guillemette, Prost, Michel, Simon, Patrick, Py, Guillaume, Blanc, Stéphane, Simon, Chantal, Bergouignan, Audrey, O’gorman, Donal |
| المساهمون: | Ecologie, Physiologie, Ethologie, Université de Strasbourg (UNISTRA), Dynamique Musculaire et Métabolisme (DMEM), Institut National de la Recherche Agronomique (INRA)-Université de Montpellier (UM), National Institute for Cellular Biotechnology & School of Health and Human Performance, Dublin City University Dublin (DCU), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Département Ecologie, Physiologie et Ethologie (DEPE-IPHC), Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Laboratoire Inflammation, Tissus épithéliaux et Cytokines (LITEC Poitiers ), Université de Poitiers = University of Poitiers (UP), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Space Medicine and Physiology, Systèmes d'élevage méditerranéens et tropicaux (UMR SELMET), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institute of Nutrition and Food sciences, Rheinische Friedrich-Wilhelms-Universität Bonn, Centre National d'Études Spatiales Toulouse (CNES), Laboratoire de recherches appliquées Spiral, Centre hospitalier Saint-Joseph Saint-Luc, Division of Endocrinology, Metabolism and Diabetes, Department of Physics Boulder, University of Colorado Boulder -University of Colorado Boulder, School of Health and Human Performance |
| المصدر: | ISSN: 8750-7587. |
| بيانات النشر: | HAL CCSD American Physiological Society |
| سنة النشر: | 2019 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | sedentary behaviors, polyphenols, countermeasure, nutrition, omega-3 fatty acids, [SDV]Life Sciences [q-bio] |
| الوصف: | CONTEXT: Physical inactivity and sedentary behaviours are independent risks factors for numerous diseases.OBJECTIVE: We examined the capacity of a nutrient cocktail composed of polyphenols, omega-3 fatty acids, vitamin E and selenium to prevent the expected metabolic alterations induced physical activity and sedentary behaviors. DESIGN/SETTING/PARTICIPANTS: Twenty healthy trained men (averaging∼14,000 steps/d and engaged in sports) were randomly divided into a control group (no supplementation) and a cocktail group for a 20-day free-living intervention during which they stopped exercise and decreased their daily steps to averaging∼3000. During the last 10 days metabolic changes were further triggered by fructose overfeeding. On days 0, 10 and 20 body composition (DXA), blood chemistry, glucose tolerance (OGTT) and substrate oxidation (indirect calorimetry) were measured. Glucose tolerance included 1% fructose labelled with (U-13C) fructose to assess liver de novo lipogenesis. Histological changes and related cellular markers were assessed from muscle biopsies collected on days 0 and 20. RESULTS: While the cocktail did not prevent the decrease in insulin sensitivity and its muscular correlates induced by the intervention, it fully prevented the hypertriglyceridemia, the drop in fasting HDL and total fat oxidation, and the increase in de novo lipogenesis. The cocktail further prevented the decrease in type-IIa muscle fiber cross-sectional area and was associated with lower protein ubiquitination content. The circulating anti-oxidant capacity was improved by the cocktail following the OGTT. CONCLUSION: A cocktail of nutrient compounds from dietary origin protects against the alterations in lipid metabolism induced by physical inactivity and fructose overfeeding. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/30284519; hal-01918097; https://hal.science/hal-01918097; https://hal.science/hal-01918097/document; https://hal.science/hal-01918097/file/2018_Daliot_JApplPhysiol_1.pdf; PRODINRA: 448772; PUBMED: 30284519; WOS: 000457357000010 |
| DOI: | 10.1152/japplphysiol.00018.2018 |
| الاتاحة: | https://hal.science/hal-01918097 https://hal.science/hal-01918097/document https://hal.science/hal-01918097/file/2018_Daliot_JApplPhysiol_1.pdf https://doi.org/10.1152/japplphysiol.00018.2018 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.C85695AB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1152/japplphysiol.00018.2018 |
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