Academic Journal
A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland
| العنوان: | A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland |
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| المؤلفون: | de Jager, Vincent D, de Visscher, Sebastiaan A H J, Schuuring, Ed, Doff, Jan J, van Kempen, Léon C |
| المصدر: | de Jager , V D , de Visscher , S A H J , Schuuring , E , Doff , J J & van Kempen , L C 2023 , ' A novel PPP2R2A::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland ' , Genes Chromosomes & Cancer , vol. 62 , no. 5 , pp. 297-300 . https://doi.org/10.1002/gcc.23122 |
| سنة النشر: | 2023 |
| المجموعة: | University of Groningen research database |
| مصطلحات موضوعية: | Female, Humans, Middle Aged, Adenocarcinoma/pathology, Salivary Glands, Transcription Factors, Salivary Gland Neoplasms/pathology, Biomarkers, Tumor/genetics, Protein Phosphatase 2/genetics |
| الوصف: | Cribriform adenocarcinoma of salivary gland (CASG) is a rare, salivary gland tumor. In this report, we describe a case of CASG harboring a novel PPP2R2A::PRKD1 fusion. A 58-year-old female presented with an intraoral mass adjacent to the lower left third molar region. Morphological features at histological examination, immunohistochemical staining (p63+, p40-), and tumor location were indicative of CASG. However, due to the potential focal presence of a biphasic component within the tumor, RNA sequencing was performed to confirm the diagnosis. The subsequently found novel PPP2R2A::PRKD1 fusion adds to the rapidly evolving molecular landscape of salivary gland tumors. Additionally, we report that CASG may show some entrapment of pre-existent salivary gland ducts, which may be misinterpreted as tumor cells with myoepithelial differentiation. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1002/gcc.23122 |
| الاتاحة: | https://hdl.handle.net/11370/d184f58f-3d9b-4ff7-937f-fc634ba53c0e https://research.rug.nl/en/publications/d184f58f-3d9b-4ff7-937f-fc634ba53c0e https://doi.org/10.1002/gcc.23122 https://pure.rug.nl/ws/files/602542355/Genes_Chromosomes_Cancer_2023_Jager_A_novel_PPP2R2A_PRKD1_fusion_in_a_cribriform_adenocarcinoma_of_salivary_gland.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C851C719 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/gcc.23122 |
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