Academic Journal
A five‐year follow‐up study of neurocognitive functioning in bipolar disorder
| العنوان: | A five‐year follow‐up study of neurocognitive functioning in bipolar disorder |
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| المؤلفون: | Santos, José Luis, Aparicio, Ana, Bagney, Alexandra, Sánchez‐Morla, Eva María, Rodríguez‐Jiménez, Roberto, Mateo, Jorge, Jiménez‐Arriero, Miguel Ángel |
| المساهمون: | Instituto de Salud Carlos III |
| المصدر: | Bipolar Disorders ; volume 16, issue 7, page 722-731 ; ISSN 1398-5647 1399-5618 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2014 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Objectives Cognitive dysfunction in bipolar disorder has been well‐established in cross‐sectional studies; however, there are few data regarding the longitudinal course of cognitive performance in bipolar disorder. The aim of this study was to examine the course of cognitive function in a sample of euthymic patients with bipolar disorder during a five‐year follow‐up period. Methods Eighty euthymic outpatients with a DSM ‐ IV diagnosis of bipolar disorder and 40 healthy control comparison subjects were neuropsychologically assessed at baseline (T1) and then at follow‐up of five years (T2). A neurocognitive battery including the main cognitive domains of speed of processing, working memory, attention, verbal memory, visual memory, and executive function was used to evaluate cognitive performance. Results Repeated‐measures multivariate analyses showed that progression of cognitive dysfunction in patients was not different to that of control subjects in any of the six cognitive domains examined. Only a measure from the verbal memory domain, delayed free recall, worsened more in patients with bipolar disorder. Additionally, it was found that clinical course during the follow‐up period did not influence the course of cognitive dysfunction. Conclusions Cognitive dysfunction that is characteristic of bipolar disorder is persistent and stable over time. Only dysfunction in verbal recall was found to show a progressive course that cannot be explained by clinical or treatment variables. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/bdi.12215 |
| الاتاحة: | http://dx.doi.org/10.1111/bdi.12215 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fbdi.12215 https://onlinelibrary.wiley.com/doi/pdf/10.1111/bdi.12215 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.C848670E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/bdi.12215 |
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