Academic Journal
Aging and chronic inflammation: highlights from a multidisciplinary workshop
| العنوان: | Aging and chronic inflammation: highlights from a multidisciplinary workshop |
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| المؤلفون: | Danay Saavedra, Ana Laura Añé-Kourí, Nir Barzilai, Calogero Caruso, Kyung-Hyun Cho, Luigi Fontana, Claudio Franceschi, Daniela Frasca, Nuris Ledón, Laura J. Niedernhofer, Karla Pereira, Paul D. Robbins, Alexa Silva, Gisela M. Suarez, Wim Vanden Berghe, Thomas von Zglinicki, Graham Pawelec, Agustín Lage |
| المصدر: | Immunity & Ageing, Vol 20, Iss 1, Pp 1-10 (2023) |
| بيانات النشر: | BMC |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Aging, Chronic inflammation, Immunosenescence, Inflammaging, Cell senescence, SASP, Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6 |
| الوصف: | Aging is a gradual, continuous series of natural changes in biological, physiological, immunological, environmental, psychological, behavioral, and social processes. Aging entails changes in the immune system characterized by a decrease in thymic output of naïve lymphocytes, an accumulated chronic antigenic stress notably caused by chronic infections such as cytomegalovirus (CMV), and immune cell senescence with acquisition of an inflammatory senescence-associated secretory phenotype (SASP). For this reason, and due to the SASP originating from other tissues, aging is commonly accompanied by low-grade chronic inflammation, termed “inflammaging”. After decades of accumulating evidence regarding age-related processes and chronic inflammation, the domain now appears mature enough to allow an integrative reinterpretation of old data. Here, we provide an overview of the topics discussed in a recent workshop “Aging and Chronic Inflammation” to which many of the major players in the field contributed. We highlight advances in systematic measurement and interpretation of biological markers of aging, as well as their implications for human health and longevity and the interventions that can be envisaged to maintain or improve immune function in older people. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1742-4933 |
| Relation: | https://doi.org/10.1186/s12979-023-00352-w; https://doaj.org/toc/1742-4933; https://doaj.org/article/4c145aa2e8744ecfa51288f777b2ec7a |
| DOI: | 10.1186/s12979-023-00352-w |
| الاتاحة: | https://doi.org/10.1186/s12979-023-00352-w https://doaj.org/article/4c145aa2e8744ecfa51288f777b2ec7a |
| رقم الانضمام: | edsbas.C83BED4B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17424933 |
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| DOI: | 10.1186/s12979-023-00352-w |