التفاصيل البيبلوغرافية
| العنوان: |
Cyclin E/CDK2 and feedback from soluble histone protein regulate the S phase burst of histone biosynthesisCyclin E/CDK2 and feedback from soluble histone protein regulate the S phase burst of histone biosynthesis ... |
| المؤلفون: |
Armstrong, Claire, Passanisi, Victor, Ashraf, Humza, Spencer, Sabrina |
| بيانات النشر: |
Mendeley Data |
| سنة النشر: |
2023 |
| المجموعة: |
DataCite Metadata Store (German National Library of Science and Technology) |
| مصطلحات موضوعية: |
Cell Biology, Microscopy |
| الوصف: |
Faithful DNA replication requires that cells fine-tune their histone pool in coordination with cell-cycle progression. Replication-dependent histone biosynthesis is initiated at a low level upon cell-cycle commitment, followed by a burst at the G1/S transition, but it remains unclear how exactly the cell regulates this change in histone biosynthesis as DNA replication begins. Here, we use single-cell timelapse imaging to elucidate the mechanisms by which cells modulate histone production during different phases of the cell cycle. We find that CDK2-mediated phosphorylation of NPAT at the Restriction Point triggers histone transcription, which results in a burst of histone mRNA precisely at the G1/S phase boundary. Excess soluble histone protein further modulates histone abundance by promoting the degradation of histone mRNA for the duration of S phase. Thus, cells regulate their histone production in strict coordination with cell-cycle progression by two distinct mechanisms acting in concert. Due to size ... |
| نوع الوثيقة: |
dataset |
| اللغة: |
unknown |
| Relation: |
https://dx.doi.org/10.17632/d2b55pmjmk.1 |
| DOI: |
10.17632/d2b55pmjmk |
| الاتاحة: |
https://dx.doi.org/10.17632/d2b55pmjmk
https://data.mendeley.com/datasets/d2b55pmjmk |
| Rights: |
Creative Commons Attribution 4.0 International ; info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/4.0/legalcode ; cc-by-4.0 |
| رقم الانضمام: |
edsbas.C82E4C6D |
| قاعدة البيانات: |
BASE |