التفاصيل البيبلوغرافية
| العنوان: |
The hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants' temperament at 3 months |
| المؤلفون: |
L.Provenzi, F. Mambretti, M.Villa, S.Grumi, A.Citterio, E.Bertazzoli, Biasucci G, L.Decembrino, R.Falcone, B.Gardella, R.Longo, R.Nacinovich, C.Pisoni, F.Prefumo, S.Orcesi, B.Scelsa, R.Giorda, R.Borgatti |
| المساهمون: |
L., Provenzi, F., Mambretti, M., Villa, S., Grumi, A., Citterio, E., Bertazzoli, Biasucci, G, L., Decembrino, R., Falcone, B., Gardella, R., Longo, R., Nacinovich, C., Pisoni, F., Prefumo, S., Orcesi, B., Scelsa, R., Giorda, R., Borgatti |
| سنة النشر: |
2021 |
| المجموعة: |
Università di Parma: CINECA IRIS |
| الوصف: |
Background: The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. Methods: In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Results: Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation (RR =.07, p =.007, B =.16 [.05;.29]). SLC6A4 methylation at these sites predicted infants’ temperament at 3 months (RR =.05, p =.027, B = -.45 [-.92;-.06]). Conclusion: Indirect effects of the pandemic may alter the trajectories of behavioral development infants. Appropriate prevention and care acts need to be adopted by healthcare systems. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000756355800055; volume:131; issue:S1-35; journal:PSYCHONEUROENDOCRINOLOGY; https://hdl.handle.net/11381/2930892 |
| الاتاحة: |
https://hdl.handle.net/11381/2930892 |
| رقم الانضمام: |
edsbas.C81FE595 |
| قاعدة البيانات: |
BASE |