Academic Journal
XBB.1, BQ1.1 and atypical BA.4.6/XBB.1 recombinants predominate current SARS-CoV-2 Wavelets with flu-like symptoms in Cameroon: A snapshot from genomic surveillance
| العنوان: | XBB.1, BQ1.1 and atypical BA.4.6/XBB.1 recombinants predominate current SARS-CoV-2 Wavelets with flu-like symptoms in Cameroon: A snapshot from genomic surveillance |
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| المؤلفون: | Fokam, Joseph, Ngoufack Jagni Semengue, Ezechiel, Gouissi Anguechia, Davy-Hyacinthe, Etame, Naomi-Karell, Takou, Désiré, Mandeng, Nadia, Kengni Ngueko, Minelle Aurelie, Beloumou Angong, Grace, Djupsa Ndjeyep, Sandrine, Chenwi Ambe, Collins, Nka, Alex Durand, Molimbou, Evariste, Mundo Nayang, Audrey Rachel, Moko Fotso, Larissa Gaëlle, Tambe Ayuk Ngwese, Derrick, Tueguem, Pamela Patricia, Tommo Tchouaket, Carlos Michel, Ka’e, Aude Christelle, Fainguem, Nadine, Abega Abega, Cyrille, Halle-Ekane, Edie-Gregory, Esso, Linda, Etoundi Mballa, Alain Georges, Shang, Judith, Ndongmo, Clement B., Cappelli, Giulia, Kifle Tessema, Sofonias, Z-K Bissek, Anne-Cecile, Colizzi, Vittorio, Ndjolo, Alexis, Perno, Carlo-Federico, Ndembi, Nicaise |
| المساهمون: | Vashist, Atul, Edctp |
| المصدر: | PLOS Global Public Health ; volume 4, issue 5, page e0003153 ; ISSN 2767-3375 |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2024 |
| المجموعة: | PLOS Publications (via CrossRef) |
| الوصف: | As of December 2022, Cameroon had observed a slight resurgence of COVID-19, raising concerns on genomic surveillance of related-SARS-CoV-2 variants under circulation. Following a laboratory-based survey, positive SARS-CoV-2 samples detected from December-2022 through March-2023 were processed for targeted sequencing at the Chantal BIYA International Reference Centre (CIRCB) in Yaoundé-Cameroon. From all positive cases detected, 13 were successfully sequenced (mean age 34 years, 70% female); the majority of the cases were unvaccinated (70%, 9/13) and symptomatic (92%, 12/13); all with flu-like symptoms (100%, 12/12). Following RT-PCR, the median cycle threshold was 22.23 [18–24] for the N gene; and 24.09 [20–26] for the ORF gene, underscoring high viral loads. Phylogenetic analysis of nucleotide sequences identified four major sub-variants in circulation, of which BA.5 (3/13), the recombinants BQ.1.1 (4/13), XBB.1 (4/13) and novel atypical variant of BA.4.6/XBB.1 (2/13). This snapshot surveillance indicates the introduction/emergence and circulation of new Omicron sub-variants, all accompanied by minor/mild symptoms. However, these new sub-variants and recombinants call for continuous genomic surveillance to prevent further resurgence of Covid-19 epidemiological wave. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1371/journal.pgph.0003153 |
| الاتاحة: | http://dx.doi.org/10.1371/journal.pgph.0003153 https://dx.plos.org/10.1371/journal.pgph.0003153 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C7FAC04B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pgph.0003153 |
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