Academic Journal
Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial
| العنوان: | Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial |
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| المؤلفون: | SANMARTIN SENTAÑES, RAMON, Varela-Sende, Luisa, Jurek, Joanna, LACASA-CAZCARRA, MARCOS, Alegre, Jose, Castro-Marrero, Jesus |
| المساهمون: | Institut Català de la Salut, Lacasa M E-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain. Alegre-Martin J, Sanmartin Sentañes R, Jurek J, Castro-Marrero J Unitat de Recerca d’Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica, Servei de Reumatologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Varela-Sende L Clinical Research Department, VITAE Health Innovation, Montmeló, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Qualitat de vida, Suplements nutritius, Síndrome de fatiga crònica - Tractament, DISEASES::Musculoskeletal Diseases::Muscular Diseases::Fatigue Syndrome, Chronic, PHENOMENA AND PROCESSES::Physiological Phenomena::Diet, Food, and Nutrition::Food::Dietary Supplements, HEALTH CARE::Environment and Public Health::Public Health::Epidemiologic Measurements::Demography::Health Status::Quality of Life, ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::síndrome de fatiga crónica, FENÓMENOS Y PROCESOS::fenómenos fisiológicos::dieta, alimentación y nutrición::alimentos::suplementos dietéticos, ATENCIÓN DE SALUD::ambiente y salud pública::salud pública::medidas epidemiológicas::demografía::estado de salud::calidad de vida |
| الوصف: | Beta-glucan; Myalgic encephalomyelitis; Vitamin B6 ; Betaglucano; Encefalomielitis miálgica; Vitamina B6 ; Betaglucà; Encefalomielitis miàlgica; Vitamina B6 ; This research aimed to examine the potential alleviative effects of beta-glucan administration on fatigue, unrefreshing sleep, anxiety/depression symptoms and health-related quality of life in ME/CFS. A 36-week unicenter, randomized, double-blind, placebo-controlled trial was conducted in 65 ME/CFS patients, who were randomly allocated to one of two arms to receive four capsules each one of 250 mg beta-glucan, 3.75 µg vitamin D3, 1.05 mg vitamin B6, and 7.5 mg zinc (n = 35), or matching placebo including only microcrystalline cellulose as an excipient (n = 30) once daily. The findings showed that the beta-glucan supplementation significantly improved cognitive fatigue (assessed with FIS-40 scores) after the 36-week treatment compared to the baseline (p = 0.0338). Taken together, this study presents the novel finding that yeast-derived beta-glucan may alleviate cognitive fatigue symptoms in ME/CFS. Thus, it offers valuable scientific insights into the potential use of yeast beta-glucan as a nutritional supplement and/or functional food to prevent or reduce cognitive dysfunction in patients with ME/CFS. Further interventions are warranted to validate these findings and also to delve deeper into the possible immunometabolic pathomechanisms of beta-glucans in ME/CFS. ; J.C.-M. received financial support and honoraria from Vitae Health Innovation S.L. (Montmeló, Barcelona, Spain). This study was supported by Vitae Health Innovation S.L. (Montmeló, Spain) which supplied both treatments (funding number: 2020-0445). |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6643 |
| Relation: | Nutrients;15(21); https://doi.org/10.3390/nu15214504; Lacasa M, Alegre-Martin J, Sanmartin Sentañes R, Varela-Sende L, Jurek J, Castro-Marrero J. Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2023 Nov;15(21):4504.; https://hdl.handle.net/11351/10770; 001103277500001 |
| DOI: | 10.3390/nu15214504 |
| الاتاحة: | https://hdl.handle.net/11351/10770 https://doi.org/10.3390/nu15214504 |
| Rights: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.C7DE571B |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20726643 |
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| DOI: | 10.3390/nu15214504 |