التفاصيل البيبلوغرافية
| العنوان: |
Harnessing Antitumor CD4+ T Cells for Cancer Immunotherapy |
| المؤلفون: |
Myriam Ben Khelil, Yann Godet, Syrine Abdeljaoued, Christophe Borg, Olivier Adotévi, Romain Loyon |
| المصدر: |
Cancers; Volume 14; Issue 1; Pages: 260 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2022 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
CD4 + T cells, cancer immunotherapy, immune checkpoint inhibitors, adoptive cell transfer, cancer vaccine |
| الوصف: |
Over the past decades, CD4+ T cells have been considered as a supporting actor in the fields of cancer immunotherapy. Until recently, accumulating evidence has demonstrated the critical role of CD4+ T cells during antitumor immunity. CD4+ T cells can either suppress or promote the antitumor cytotoxic CD8+ T cell responses, either in secondary lymphoid organs or in the tumor. In this review, we provide an overview of the multifaceted role of different CD4+ T cell subsets in cancer immune response and their contribution during cancer therapies. Specifically, we focus on the latest progress regarding the impact of CD4+ T cell modulation on immunotherapies and other cancer therapies and discuss the prospect for harnessing CD4+ T cells to control tumor progression and prevent recurrence in patients. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Cancer Biology; https://dx.doi.org/10.3390/cancers14010260 |
| DOI: |
10.3390/cancers14010260 |
| الاتاحة: |
https://doi.org/10.3390/cancers14010260 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.C7D69371 |
| قاعدة البيانات: |
BASE |