Academic Journal
Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
| العنوان: | Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells |
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| المؤلفون: | Monteil V. M., Wright S. C., Dyczynski M., Kellner M. J., Appelberg S., Platzer S. W., Ibrahim A., Kwon H., Pittarokoilis I., Mirandola M., Michlits G., Devignot S., Elder E., Abdurahman S., Bereczky S., Bagci B., Youhanna S., Aastrup T., Lauschke V. M., Salata C., Elaldi N., Weber F., Monserrat N., Hawman D. W., Feldmann H., Horn M., Penninger J. M., Mirazimi A. |
| المساهمون: | Monteil, V. M., Wright, S. C., Dyczynski, M., Kellner, M. J., Appelberg, S., Platzer, S. W., Ibrahim, A., Kwon, H., Pittarokoilis, I., Mirandola, M., Michlits, G., Devignot, S., Elder, E., Abdurahman, S., Bereczky, S., Bagci, B., Youhanna, S., Aastrup, T., Lauschke, V. M., Salata, C., Elaldi, N., Weber, F., Monserrat, N., Hawman, D. W., Feldmann, H., Horn, M., Penninger, J. M., Mirazimi, A. |
| بيانات النشر: | Nature Research |
| سنة النشر: | 2024 |
| المجموعة: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| مصطلحات موضوعية: | CCHFV, receptor, screening, aploid cells, organoids, LDLR |
| الوصف: | Climate change and population densities accelerated transmission of highly pathogenic viruses to humans, including the Crimean–Congo haemorrhagic fever virus (CCHFV). Here we report that the Low Density Lipoprotein Receptor (LDLR) is a critical receptor for CCHFV cell entry, playing a vital role in CCHFV infection in cell culture and blood vessel organoids. The interaction between CCHFV and LDLR is highly specific, with other members of the LDLR protein family failing to bind to or neutralize the virus. Biosensor experiments demonstrate that LDLR specifically binds the surface glycoproteins of CCHFV. Importantly, mice lacking LDLR exhibit a delay in CCHFV-induced disease. Furthermore, we identified the presence of Apolipoprotein E (ApoE) on CCHFV particles. Our findings highlight the essential role of LDLR in CCHFV infection, irrespective of ApoE presence, when the virus is produced in tick cells. This discovery holds profound implications for the development of future therapies against CCHFV. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38548922; info:eu-repo/semantics/altIdentifier/wos/WOS:001194694400002; journal:NATURE MICROBIOLOGY; https://hdl.handle.net/11577/3511914; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85188880184; https://www.nature.com/articles/s41564-024-01672-3 |
| DOI: | 10.1038/s41564-024-01672-3 |
| الاتاحة: | https://hdl.handle.net/11577/3511914 https://doi.org/10.1038/s41564-024-01672-3 https://www.nature.com/articles/s41564-024-01672-3 |
| رقم الانضمام: | edsbas.C7A5A80E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41564-024-01672-3 |
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