Academic Journal
Single-step pulsed electrodeposition of calcium phosphate coatings on titanium for drug delivery
| العنوان: | Single-step pulsed electrodeposition of calcium phosphate coatings on titanium for drug delivery |
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| المؤلفون: | Vidal Girona, Elia, Buxadera Palomero, Judit, Pierre, Camille, Manero Planella, José María, Ginebra Molins, Maria Pau, Cazalbou, Sophie, Combes, Christele, Rupérez de Gracia, Elisa, Rodríguez Rius, Daniel |
| المساهمون: | Universitat Politècnica de Catalunya. Departament de Ciència dels Materials i Enginyeria Metal·lúrgica, Universitat Politècnica de Catalunya. BBT - Biomaterials, Biomecànica i Enginyeria de Teixits |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2019 |
| المجموعة: | Universitat Politècnica de Catalunya (UPC): Tesis Doctorals en Xarxa (TDX) / Theses and Dissertations Online |
| مصطلحات موضوعية: | Àrees temàtiques de la UPC::Enginyeria dels materials, Biomedical materials, Tissue engineering, Calcium phosphate, Titanium, Coating, Pulse electrodeposition, Antibacterial agent, Characterization, Enginyeria de teixits, Fosfat de calci -- Aplicacions mèdiques, Titani -- Aplicacions mèdiques, Materials biomèdics |
| الوصف: | Metallic implants have some limitations related to bioactivity and bacteria colonization leading to infections. In this regard, calcium phosphate coatings can be used as carrier for drug delivery in order to improve the mentioned drawbacks. The present work proposes the introduction of an antibacterial agent in the course of a pulsed and reverse pulsed electrodeposition. Calcium phosphate coatings were prepared in 30¿min using different pulse waveforms (unipolar-bipolar), current densities (2–5¿mA/cm2) and temperatures (40–60¿°C). Mechanical stability of the as-coated surfaces was studied in order to select the optimal electrodeposition conditions. Subsequently, selected coatings were loaded with an antiseptic agent, chlorhexidine digluconate (CHX), via a single-step co-deposition procedure. CHX concentration added to the electrolyte was adjusted to 3¿mM based on the antibacterial efficacy of the loaded coatings evaluated in vitro with Staphylococcus aureus and Escherichia coli bacteria strains. Whereas the same chlorhexidine concentration was added to the electrolyte, results showed that the amount of CHX loaded was different for each condition while release kinetics was maintained. The results of this work demonstrate that a pulsed co-deposition strategy has great potential to modulate local delivery of antibacterial agents such as chlorhexidine digluconate, which may prevent early phase infections of metallic implants after insertion. ; Postprint (author's final draft) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 10 p. |
| اللغة: | English |
| تدمد: | 0257-8972 |
| Relation: | https://www.sciencedirect.com/science/article/abs/pii/S0257897218312477?via%3Dihub; info:eu-repo/grantAgreement/AGAUR/1PE/2014 SGR 1333; info:eu-repo/grantAgreement/MINECO/1PE/MAT2015-67183-R; info:eu-repo/grantAgreement/EC/1PE/COST Action TD1305; Vidal, E., Buxadera-Palomero, J., Pierre, C., Manero, J., Ginebra, M.P., Cazalbou, S., Combes, C., Rupérez de Gracia, E., Rodriguez, D. Single-step pulsed electrodeposition of calcium phosphate coatings on titanium for drug delivery. "Surface and coatings technology", 25 Gener 2019, vol. 358, p. 266-275.; http://hdl.handle.net/2117/125972 |
| DOI: | 10.1016/j.surfcoat.2018.11.037 |
| الاتاحة: | http://hdl.handle.net/2117/125972 https://doi.org/10.1016/j.surfcoat.2018.11.037 |
| Rights: | Attribution-NonCommercial-NoDerivs 3.0 Spain ; http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ; Restricted access - publisher's policy |
| رقم الانضمام: | edsbas.C79AEEB9 |
| قاعدة البيانات: | BASE |
| تدمد: | 02578972 |
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| DOI: | 10.1016/j.surfcoat.2018.11.037 |