Academic Journal
Titanium complexes bearing 2,6‐bis(o‐hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple‐negative breast‐cancer cells
| العنوان: | Titanium complexes bearing 2,6‐bis(o‐hydroxyalkyl)pyridine ligands in vitro cytotoxicity against triple‐negative breast‐cancer cells |
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| المؤلفون: | Chen, I‐Ni, Ganta, Prasanna Kumar, Chung, Shou‐Jie, Chang, Yu‐Lun, Chang, Heng‐Yi, Ding, Shangwu, Chen, Hsuan‐Ying, Chiu, Chien‐Chih, Wu, Kuo‐Hui |
| المساهمون: | Kaohsiung Medical University, Ministry of Science and Technology, Taiwan |
| المصدر: | Journal of the Chinese Chemical Society ; volume 68, issue 5, page 871-877 ; ISSN 0009-4536 2192-6549 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Three titanium (Ti) compounds bearing 2,6‐bis( o ‐hydroxyalkyl)pyridine ligands were synthesized, and used in vitro cytotoxicity against triple‐negative breast cancer (TNBC) MDA‐MB‐231 cells was studied. The results of in vitro cytotoxicity of the complexes against TNBC cells revealed that ( H L Me Ti‐O) 4 (IC 50 = 0.91 μ M) exerted a significant inhibitory effect on the proliferation of TNBC cells. Thus, titanium alkoxide complexes as nonplatinum complex could be used for structural optimization for treating breast cancer cells in the future. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/jccs.202000393 |
| الاتاحة: | http://dx.doi.org/10.1002/jccs.202000393 https://onlinelibrary.wiley.com/doi/pdf/10.1002/jccs.202000393 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/jccs.202000393 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.C7940FF0 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/jccs.202000393 |
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