التفاصيل البيبلوغرافية
| العنوان: |
Increased risk of subsequent neoplasm after hematopoietic stem cell transplantation in 5-year survivors of childhood acute lymphoblastic leukemia |
| المؤلفون: |
Westerveld, Aimée S R, Roesthuis, Pien, van der Pal, Helena J H, Bresters, Dorine, Bierings, Marc, Loonen, Jacqueline, de Vries, Andrica C H, Louwerens, Marloes, Koopman, Maria M W, van den Heuvel-Eibrink, Marry M, van der Heiden-van der Loo, Margriet, Hoogerbrugge, Peter, Janssens, Geert O, de Krijger, Ronald R, Ronckers, Cecile M, Pieters, Rob, Kremer, Leontien C M, Teepen, Jop C |
| المساهمون: |
Cancer, MS Radiotherapie, Pathologie Pathologen staf, Zorg en O&O, Child Health |
| سنة النشر: |
2024 |
| مصطلحات موضوعية: |
Adolescent, Adult, Cancer Survivors/statistics & numerical data, Child, Preschool, Female, Hematopoietic Stem Cell Transplantation/adverse effects, Humans, Incidence, Infant, Male, Neoplasms, Second Primary/epidemiology, Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy, Risk Factors, Young Adult, Journal Article |
| الوصف: |
Acute lymphoblastic leukemia (ALL) survivors are at risk for developing subsequent neoplasms, but there is limited information on long-term risks and risk factors for both subsequent malignant neoplasms (SMNs) and subsequent non-malignant neoplasms (SNMNs). We analyzed long-term risk and risk factors for SMNs and SNMNs among 3291 5-year ALL survivors from the Dutch Childhood Cancer Survivor Study-LATER cohort (1963-2014). We calculated standardized incidence ratios (SIRs) and cumulative incidences and used multivariable Cox proportional hazard regression analyses for analyzing risk factors. A total of 97 survivors developed SMNs and 266 SNMNs. The 30-year cumulative incidence was 4.1% (95%CI: 3.5-5.3) for SMNs and 10.4%(95%CI: 8.9-12.1) for SNMNs. Risk of SMNs was elevated compared to the general population (SIR: 2.6, 95%CI: 2.1-3.1). Survivors treated with hematopoietic stem cell transplantation (HSCT) with total body irradiation (TBI) (HR:4.2, 95%CI: 2.3-7.9), and without TBI (HR:4.0,95%CI: 1.2-13.7) showed increased SMN risk versus non-transplanted survivors. Cranial radiotherapy (CRT) was also a risk factor for SMNs (HR:2.1, 95%CI: 1.4-4.0). In conclusion, childhood ALL survivors have an increased SMN risk, especially after HSCT and CRT. A key finding is that even HSCT-treated survivors without TBI treatment showed an increased SMN risk, possibly due to accompanied chemotherapy treatment. This emphasizes the need for careful follow-up of HSCT and/or CRT-treated survivors. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| تدمد: |
2044-5385 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/455759 |
| الاتاحة: |
https://dspace.library.uu.nl/handle/1874/455759 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: |
edsbas.C7934944 |
| قاعدة البيانات: |
BASE |
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