Academic Journal
Detecting motor unit abnormalities in amyotrophic lateral sclerosis using high-density surface EMG
| العنوان: | Detecting motor unit abnormalities in amyotrophic lateral sclerosis using high-density surface EMG |
|---|---|
| المؤلفون: | Nishikawa Yuichi, Holobar Aleš, Watanabe Kohei, Takahashi Tetsuya, Ueno Hiroki, Maeda Noriaki, Maruyama Hirofumi, Tanaka Shinobu, Hyngstrom Allison S., 西川 裕一, 田中 志信 |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Kanazawa University Repository for Academic Resources (KURA) / 金沢大学学術情報リポジトリ |
| مصطلحات موضوعية: | Amyotrophic lateral sclerosis, electromyography, motor unit recruitment |
| الوصف: | 金沢大学理工研究域フロンティア工学系 ; ObjectiveThe purpose of this study was to detect specific motor unit (MU) abnormalities in people with amyotrophic lateral sclerosis (ALS) compared to controls using high-density surface electromyography (HD-SEMG).MethodsSixteen people with ALS and 16 control subjects. The participants performed ramp up and sustained contractions at 30% of their maximal voluntary contraction. HD-SEMG signals were recorded in the vastus lateralis muscle and decomposed into individual MU firing behavior using a convolution blind source separation method.ResultsIn total, 339 MUs were detected (people with ALS; n=93, control subjects; n=246). People with ALS showed significantly higher mean firing rate, recruitment threshold, coefficient of variation of the MU firing rate, MU firing rate at recruitment, and motoneurons excitability than those of control subjects (p<0.001). The number of MU, MU firing rate, recruitment threshold, and MU firing rate at recruitment were significantly correlated with disease severity (p<0.001). Multivariable analysis revealed that an increased MU firing rate at recruitment was independently associated with ALS.ConclusionsThese results suggest increased excitability at recruitment, which is consistent with neurodegeneration results in a compensatory increase in MU activity.SignificanceAbnormal MU firing behavior provides an important physiological index for understanding the pathophysiology of ALS. ; Embargo Period 12 months |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1388-2457 |
| Relation: | https://www.sciencedirect.com/journal/clinical-neurophysiology; https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=60704; http://hdl.handle.net/2297/00066951; Clinical Neurophysiology, 142, 262-272(2022-10-01); AA11309888; https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=60704&item_no=1&attribute_id=26&file_no=1 |
| الاتاحة: | http://hdl.handle.net/2297/00066951 https://kanazawa-u.repo.nii.ac.jp/?action=repository_uri&item_id=60704 https://kanazawa-u.repo.nii.ac.jp/?action=repository_action_common_download&item_id=60704&item_no=1&attribute_id=26&file_no=1 |
| Rights: | Copyright © Elsevier (CC-BY-NC-ND) |
| رقم الانضمام: | edsbas.C769EA05 |
| قاعدة البيانات: | BASE |
| تدمد: | 13882457 |
|---|