Academic Journal
CPC13 BRAF mutated and morphologically Spitz naevi and tumours: a series of four cases
| العنوان: | CPC13 BRAF mutated and morphologically Spitz naevi and tumours: a series of four cases |
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| المؤلفون: | Daruish, Maged, Goodyear, Helen, Lemahieu, Julie, Taibjee, Saleem |
| المصدر: | British Journal of Dermatology ; volume 191, issue Supplement_1, page i13-i14 ; ISSN 0007-0963 1365-2133 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2024 |
| الوصف: | The current World Health Organization classification of skin tumours (5th edition) indicates that melanocytic tumours of the Spitz pathway can be defined by mutually exclusive oncogenic drivers, including HRAS-activating mutations or kinase fusions. Accordingly, the term ‘spitzoid’ has been suggested for tumours that show morphological features of Spitz tumours but lack these defining molecular aberrations. Such neoplasms harbouring BRAF or NRAS mutations include a subtype of melanomas with confirmed risk of local recurrence and metastasis. In contrast, a recent study described a subset of Spitz-looking neoplasms with BRAF mutations and insufficient criteria for melanoma (Zhao J, Benton S, Zhang B et al. Benign and intermediate-grade melanocytic tumours with BRAF mutations and Spitzoid morphology. Am J Surg Pathol 2022; 46: 476–85). The term BRAF mutated and morphologically spitzoid naevi/tumours (BAMS) was proposed for such lesions. We present a series of four cases of BAMS. The patients ranged in age from 3 to 40 years; three were male and one was female. The clinical history varied from new growing moles to change within long-standing lesions, congenital in one instance. One lesion was submitted with the query of halo naevus. Anatomical sites included the abdomen, pubis, right buttock and left upper back. In one of our cases the clinical appearance, including starburst pattern on dermoscopy, was very suggestive of a pigmented Spitz naevus. All cases showed a predominantly epithelioid cytomorphology with accompanying melanophages. The cytoplasmic pigment was prominent in three cases. Three of the neoplasms were compound, with evidence of maturation with depth. The case described clinically as a changing congenital lesion had a mild degree of cytological atypia, a single superficial mitosis and focal PReferentially expressed Antigen in MElanoma positivity. In this case there was bridging of nests and lamellar fibroplasia, indicating overlapping features with Clark dysplastic naevus. Three cases had ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/bjd/ljae090.026 |
| الاتاحة: | http://dx.doi.org/10.1093/bjd/ljae090.026 https://academic.oup.com/bjd/article-pdf/191/Supplement_1/i13/58328437/ljae090.026.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.C7419764 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/bjd/ljae090.026 |
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